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Advancements in Microfluidic Technologies and BioMEMS

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 189

Special Issue Editors


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Guest Editor
Agricultural & Biological Engineering Department, Purdue University, West Lafayette, IN, USA
Interests: bioastronautics; biophysics; space biology; gravitational biology; space agriculture
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Sensors and MicroActuators Learning Lab (SMALL), Department of Electrical Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA
2. Department of Biomedical Engineering, University at Buffalo, State University of New York (SUNY-Buffalo), Buffalo, NY 14260, USA
Interests: bioMEMS; lab-on-a-chip (LOC); microfluidics; droplet-based microfluidics; blood separation; micro PCR; micro SERS; sensors for LOC
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK
Interests: microfluidics; biosensors; optical sensors; chemical sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are witnessing a remarkable era of innovation in the field of microfluidic technologies and BioMEMS, shaping the future of biomedical research and applications. The integration of advanced microfabrication techniques with biological sciences has led to the emergence of novel platforms like the lab-on-a-chip and organ-on-a-chip, revolutionizing our approach towards disease modeling, drug development, and personalized medicine. This Special Issue, "Advancements in Microfluidic Technologies and BioMEMS", aims to showcase cutting-edge research and developments in this dynamic field. 

We invite contributions that highlight the latest advancements, challenges, and future perspectives in microfluidics and BioMEMS. Submissions can range from technical papers and industrial case studies to comprehensive review articles. We are particularly interested in works focusing on, but not limited to, the following areas: 

  • Development and application of organ-on-a-chip platforms;
  • Innovations in lab-on-a-chip technologies for biomedical applications;
  • Integration of microfluidics with point-of-care diagnostics;
  • Advancements in microfabrication techniques for BioMEMS;
  • Personalized medicine approaches utilizing microfluidic devices;
  • Advances in sensing technology for the lab-on-a-chip.

Your contributions will be pivotal in shaping the understanding and application of microfluidic technologies and BioMEMS in the biomedical field. We look forward to your valuable insights and discoveries.

Prof. Dr. D. Marshall Marshall Porterfield
Prof. Dr. Kwang W. Oh
Dr. Christabel Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • BioMEMS
  • lab-on-a-chip
  • organ-on-a-chip
  • point-of-care technologies

Published Papers (1 paper)

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Research

15 pages, 3372 KiB  
Article
A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section
by Shijie Lu, Ding Ma and Xianqiang Mi
Sensors 2024, 24(11), 3552; https://doi.org/10.3390/s24113552 - 31 May 2024
Abstract
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a [...] Read more.
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a large number of cells. In this paper, a new spiral microfluidic chip with asymmetric cross-section is proposed for rapid, high-throughput, label-free enrichment of CTCs in peripheral blood. A mold of the desired flow channel structure was prepared and inverted to make a trapezoidal cross-section using a micro-nanotechnology process of 3D printing. After a systematic study of how flow rate, channel width, and particle concentration affect the performance of the device, we utilized the device to simulate cell sorting of 6 μm, 15 μm, and 25 μm PS (Polystyrene) particles, and the separation efficiency and separation purity of 25 μm PS particles reached 98.3% and 96.4%. On this basis, we realize the enrichment of a large number of CTCs in diluted whole blood (5 mL). The results show that the separation efficiency of A549 was 88.9% and the separation purity was 96.4% at a high throughput of 1400 μL/min. In conclusion, we believe that the developed method is relevant for efficient recovery from whole blood and beneficial for future automated clinical analysis. Full article
(This article belongs to the Special Issue Advancements in Microfluidic Technologies and BioMEMS)
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