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Article

Synthesis of Some New 2-(3-Aryl-1-phenyl-4-pyrazolyl)-benzoxazoles Using Hypervalent Iodine Mediated Oxidative Cyclization of Schiff’s Bases

Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana 136 119, India
*
Author to whom correspondence should be addressed.
Molecules 2006, 11(1), 43-48; https://doi.org/10.3390/11010043
Submission received: 10 November 2004 / Revised: 6 July 2004 / Accepted: 6 July 2005 / Published: 31 January 2006

Abstract

:
Ten new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles have been synthesized by oxidative intramolecular cyclization of the corresponding Schiff’s bases using iodobenzene diacetate in methanol as an oxidant.

Introduction

In connection with our ongoing programme directed towards the use of organoiodine(III) compounds as unique reagents in organic synthesis [1,2], we have recently reported that oxidation of phenolic Schiff’s bases (SBs) with iodobenzene diacetate (IBD) leads to facile intramolecular cyclization, thus providing an efficient synthesis of 2-substituted benzoxazoles (Scheme 1) [3]. This observation, coupled with the fact that benzoxazoles [4] and pyrazoles [5] are often associated with important biological properties, prompted us to extend the scope of this iodine(III) mediated approach to the synthesis of some new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles 4aa-4be.
Scheme 1.
Scheme 1.
Molecules 11 00043 g001

Results and Discussion

First we prepared Schiff’s base 3aa by the condensation of o-aminophenol (1a) with 4-formyl-1,3- diphenylpyrazole (2a). Then, oxidation of 3aa was tried using our previously reported procedure involving 1.1 equivalents of IBD in dichloromethane. The reaction occurred readily, but the yield of the expected product 4aa was not good (only 24%). Interestingly, using methanol as a solvent in this reaction, compound 4aa was obtained in noticeably improved yield (60%). In order to study the scope of this approach, other Schiff’s bases 3aa-3be, available by the condensation of 1a or 1b with different formylpyrazoles 2a-e, were subjected to oxidative cyclization using 1.1 equivalents of IBD in methanol. The reaction, indeed, afforded the desired benzoxazole derivatives 4aa-4be in yields ranging from 55% to 88% (Scheme 2, Table 1).
Scheme 2.
Scheme 2.
Molecules 11 00043 g002
The formylpyrazoles 2a-e needed in this study were prepared by Vilsmeier-Haack reaction of acetophenone phenylhydrazones (Scheme 3) [6]. The formylpyrazoles 2a and 2e are known compounds [6] and were identified by comparison of their melting points with those reported in the literature. The products 2b-2d are new compounds and were characterized by their spectral data.
The products 3aa-3be and 4aa-4be are also all new compounds and their structures were established by spectral and elemental analysis data. Schiff’s bases 3aa-3be were characterized by the absence of the 1674 cm−1(C=O stretch) signal and presence of a broad weak signal at 3360 cm−1(O-H stretch) in their IR spectra. A distinctive feature of their 1H-NMR spectra was presence of two singlets between 8.3 δ- 8.8 δ corresponding to the C5-H and CH=N protons (Table 2). The intramolecular cyclization of Schiff’s bases to 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles 4aa-4be was characterized by the disapperance of the 3360 cm−1 (O-H stretch) signal in the IR spectra, a downfield shift of the C5-H proton as a result of the cyclization and the disappearance of the CH=N proton signal in the corresponding 1H-NMR spectra (Table 2).
Scheme 3.
Scheme 3.
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Conclusions

In summary, the synthesis of new pyrazolylbenzoxazoles reported in this study provides a novel example of an attractive and effective iodine(III) mediated heterocyclic synthesis. The organoiodine (III) mediated approach described is preferred over the existing methods because of the less toxic nature of these reagents compared to other oxidants previously used in this type of transformation, namely, lead tetraacetate [7], nickel peroxide [8], copper (I) chloride in the presence of dioxygen [9], which are highly toxic.

Experimental

General

All reagents were purchased from commercial sources and were used without further purification. Melting points were taken in open capillaries and are uncorrected. 1H-NMR spectra were recorded on a Bruker 300 MHz instrument using TMS as an internal standard. IR spectra were recorded on a Buck Scientific IR M-500 spectrophotometer. Yields, physical properties (m.p.) and spectroscopic data of the prepared compounds are summarized in Table 1 and Table 2.

General Method for the Preparation of 3-Aryl-4-formyl-1-phenylpyrazoles 2a-e:

The appropriate acetophenone phenylhydrazone (15 mmol) was added to a cold solution of dimethylformamide (25 mL) and phosphorus oxychloride (5 mL), and the resulting mixture was stirred at 50-60 °C for 5-6 hrs, then cooled to room temperature and poured into ice-cold water. A saturated solution of sodium bicarbonate was added to neutralize the mixture and thus give formylpyrazoles 2a-e, which were isolated by filtration, followed by washing with water. 2a: M.p. 137-138 °C, (Lit. [6] m.p. 140 °C); 2b: M.p. 110-113 °C, 1H-NMR (CDCl3) δ: 6.9- 7.2 (m, 9 H, aromatic protons), 8.5 (s, 1H, C5-H), 9.96 (s, 1H, CHO). IR (νmax, KBr): 1674 cm−1 (C=O); 2c: M.p. 100-102 °C, 1H-NMR (CDCl3) δ: 3.83 (s, 3 H, OCH3), 6.7-7.1 (m, 9 H, aromatic protons), 8.46 (s, 1 H, C5-H), 9.98 (s, 1 H, CHO). IR (νmax, KBr): 1678 cm−1 (C=O); 2d: M.p. 120-122 °C, 1H-NMR (CDCl3) δ: 1.5 (s, 3 H, CH3), 6.8-7.6 (m, 9 H, aromatic protons), 8.57 (s, 1 H, C5-H), 9.87 (s, 1 H, CHO). IR (νmax, KBr): 1680 cm−1 (C=O); 2e: 163-164 °C, (Lit. [6] m.p. 165 °C).

General Method for the Synthesis of Schiff’s bases (SBs) 3aa-3be:

SBs were prepared by refluxing a solution of the appropriate formylpyrazole 2a-e (20 mmol) and o-aminophenol/p-chloro-o-aminophenol (1a-b, 30 mmol) in ethanol (100 mL) for 45-60 minutes. The solid product thus obtained was filtered off and recrystallised from ethanol. The physical and spectral data of the products are listed in Table 2.

General Method for the Synthesis of 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles 4aa-4be from 3aa- 3be:

To a solution of the appropriate Schiff’s base 3aa-be (10 mmol) in methanol (10 mL) was added IBD (11 mmol) and the mixture was stirred for 45-50 minutes at room temperature. The solid separated was filtered off and washed with methanol. The crude product thus obtained was recrystallized from ethanol. The physical and spectral data of the pure products are listed in Table 1.
Table 1. Physical and 1H-NMR data of 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles 4aa-4be
Table 1. Physical and 1H-NMR data of 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles 4aa-4be
Comp.am.p. (°C)Yieldb (%)1H-NMR (δ)
4aa141-142606.84-7.84 (m, 14 H, aromatic protons), 8.65 (s, 1 H, C5-H)
4ab186-187817.34-8.05 (m, 13 H, aromatic protons), 8.74 (s, 1 H, C5-H)
4ac166-168643.89 (s, 3 H, OCH3), 7.02-7.99 (m, 13 H, aromatic protons), 8.71 (s, 1 H, C5-H)
4ad142-145581.5 (s, 3 H, CH3), 7.18-7.94 (m, 13 H, aromatic protons), 8.53 (s, 1 H, C5-H)
4ae122-124617.19-8.21 (m, 13 H, aromatic protons), 8.65 (s, 1 H, C5-H)
4ba137-139737.22-7.92 (m, 13 H, aromatic protons), 8.65 (s, 1 H, C5-H)
4bb160-161787.20-7.93 (m, 12H, aromatic protons), 8.63 (s, 1H, C5-H)
4bc128-129723.83 (s, 3 H, OCH3), 6.94-7.9 (m, 12 H, aromatic protons) 8.63 (s, 1 H, C5-H)
4bd148-150551.5 (s, 3 H, CH3), 6.81-7.93 (m, 12 H, aromatic protons), 8.65 (s, 1 H, C5-H)
4be240-24276c
a These are new products and their obtained elemental analyses (C, H, N) were satisfactory.
b Yields of isolated pure product based on the amount of Schiff’s base employed.
c 1H-NMR could not be recorded because of solubility problems.
Table 2. Physical and spectral data of Schiff’s bases 3aa-3be
Table 2. Physical and spectral data of Schiff’s bases 3aa-3be
Comp.am.p.(°C)Yieldb (%)IR (O-H str cm−1)1H-NMR (δ)
3aa143-1447633516.84-7.84 (m, 14 H, aromatic protons), 8.60 (s, 1 H, C5-H), 8.73 (s, 1 H, HC=N)
3ab142-1437233906.98-7.84 (m, 13 H, aromatic protons), 8.58 (s, 1 H, C5-H), 8.69 (s, 1 H, HC=N)
3ac146-1478133753.89 (s, 3 H, OCH3), 7.02-7.99 (m, 13 H, aromatic protons), 8.58 (s, 1 H, C5-H), 8.71 (s, 1 H, HC=N)
3ad126-1285833481.5 (s, 3 H, CH3), 7.18-7.94 (m, 13 H, aromatic protons), 8.42 (s, 1 H, C5-H), 8.65 (s, 1 H, HC=N)
3ae100-1016133457.19-8.21 (m, 13 H, aromatic protons), 8.52 (s, 1 H, C5-H), 8.64 (s, 1 H, HC=N)
3ba182-1837833606.89-7.77 (m, 13 H, aromatic protons), 8.52 (s, 1 H, C5-H), 8.59 (s, 1 H, HC=N)
3bb240-2427933597.20-7.93 (m, 12 H, aromatic protons), 8.54 (s, 1 H, C5-H), 8.66 (s, 1 H, HC=N)
3bc128-1297233723.83 (s, 3 H, OCH3), 6.94-7.9 (m, 12 H, aromatic protons), 8.47 (s, 1 H, C5-H), 8.59 (s, 1 H, HC=N)
3bd160-1625533581.5 (s, 3 H, CH3), 6.81-7.93 (m, 12 H, aromatic protons), 8.53 (s, 1 H, C5-H), 8.62 (s, 1 H, HC=N)
3be252-254863414c
a These are new products and their obtained elemental analyses (C, H, N) were satisfactory.
b Yields of Schiff’s bases based on the amount of formylpyrazole used.
c 1H-NMR could not be recorded due to poor solubility.

Acknowledgements

We are thankful to Kurukshetra University, Kurukshetra, for the award of a University Research Fellowship to Kamaljeet Pannu and to DRDO (ERIP/ER/0103294/M/01), New Delhi, for the award of a Senior Research Fellowship to Ajay Kumar to carry out this work.

References:

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  • Sample Availability: Samples available from the authors.

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MDPI and ACS Style

Prakash, O.; Pannu, K.; Kumar, A. Synthesis of Some New 2-(3-Aryl-1-phenyl-4-pyrazolyl)-benzoxazoles Using Hypervalent Iodine Mediated Oxidative Cyclization of Schiff’s Bases. Molecules 2006, 11, 43-48. https://doi.org/10.3390/11010043

AMA Style

Prakash O, Pannu K, Kumar A. Synthesis of Some New 2-(3-Aryl-1-phenyl-4-pyrazolyl)-benzoxazoles Using Hypervalent Iodine Mediated Oxidative Cyclization of Schiff’s Bases. Molecules. 2006; 11(1):43-48. https://doi.org/10.3390/11010043

Chicago/Turabian Style

Prakash, Om, Kamaljeet Pannu, and Ajay Kumar. 2006. "Synthesis of Some New 2-(3-Aryl-1-phenyl-4-pyrazolyl)-benzoxazoles Using Hypervalent Iodine Mediated Oxidative Cyclization of Schiff’s Bases" Molecules 11, no. 1: 43-48. https://doi.org/10.3390/11010043

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