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391 KiB

Open AccessArticle

Microwave Assisted Synthesis of Molybdenum and Tungsten Tetracarbonyl Complexes with a Pyrazolylpyridine Ligand. Crystal structure of cis-[Mo(CO)₄{ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate}]

by Ana C. Coelho, Filipe A. Almeida Paz, Jacek Klinowski, Martyn Pillinger and Isabel S. Gonçalves

Molecules 2006, 11(12), 940-952; https://doi.org/10.3390/molecules11120940 - 06 Dec 2006

Cited by 7 | Viewed by 11181

Abstract

We report the one-step syntheses in good yields of the complexes cis-[M(CO)₄(pzpy)] {M = Mo, W; pzpy = ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate} directlyfrom the corresponding M(CO)₆ starting materials by using microwave-assisted heatingand reaction times of either 30 s (M = Mo) or 15 [...] Read more.

We report the one-step syntheses in good yields of the complexes cis-[M(CO)₄(pzpy)] {M = Mo, W; pzpy = ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate} directlyfrom the corresponding M(CO)₆ starting materials by using microwave-assisted heatingand reaction times of either 30 s (M = Mo) or 15 min (M = W). The structure of themolybdenum tetracarbonyl complex was determined by single crystal X-ray diffraction.The compound is monomeric and the molybdenum atom has a highly distorted octahedralgeometry. The close packing of the individual cis-[Mo(CO)4(pzpy)] species is essentiallydriven by the need to fill the space effectively, closely mediated by weak C–H···O andπ···π interactions. Full article

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48 KiB

Open AccessCommunication

Synthesis and Characterization of Dimethacrylate Monomer with High Molecular Weight for Root Canal Filling Materials

by Fang Liu, Jing-wie He, Zheng-mei Lin, Jun-qi Ling and De-min Jia

Molecules 2006, 11(12), 953-958; https://doi.org/10.3390/11120953 - 07 Dec 2006

Cited by 12 | Viewed by 10383

Abstract

A new dimethacrylate monomer 9,9'-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)phenyl] fluorene (3) with a molecular weight of 634 was synthesized in 51.4%yield by addition of a glycidyl ether group to 9,9'-bis(4-hydroxyphenyl) fluorene (1) bythe reaction of compound 1 with epichlorohydrin, and then introducing the methacrylatemoiety by the reaction [...] Read more.

A new dimethacrylate monomer 9,9'-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)phenyl] fluorene (3) with a molecular weight of 634 was synthesized in 51.4%yield by addition of a glycidyl ether group to 9,9'-bis(4-hydroxyphenyl) fluorene (1) bythe reaction of compound 1 with epichlorohydrin, and then introducing the methacrylatemoiety by the reaction of the epoxy group with methacrylic acid. The structure ofmonomer 3 was confirmed by FT-IR, ¹H-NMR, mass spectra and elemental analysis. Full article

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74 KiB

Open AccessArticle

Synthesis of (R)-2-(Benzyloxy)-tetrahydro-5,5-dimethylfuran by a New Oxidative Rearrangement

by D. Díez, M. G. Nuñez, R. F. Moro, N. M. Garrido, I. S. Marcos, P. Basabe and J. G. Urones

Molecules 2006, 11(12), 959-967; https://doi.org/10.3390/11120959 - 18 Dec 2006

Cited by 2 | Viewed by 8482

Abstract

The rearrangement under oxidative conditions of 3-(benzyloxy)-tetrahydro- 2,6,6-trimethyl-2H-pyran-2-carbaldehydes to afford a chiral protected tetrahydrofuran lactol is described. Full article

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61 KiB

Open AccessCommunication

Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

by Mario Sechi, Fabio Casu, Ilaria Campesi, Stefano Fiori and Alberto Mariani

Molecules 2006, 11(12), 968-977; https://doi.org/10.3390/11120968 - 18 Dec 2006

Cited by 7 | Viewed by 8410

Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds. Full article

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81 KiB

Open AccessArticle

CuCl₂-catalyzed One-pot Formation of Tetrahydroquinolines from N-Methyl-N-alkylanilines and Vinyl Ethers in the Presence of t-Butylhydroperoxide

by Xianghua Yang, Chanjuan Xi and Yanfeng Jiang

Molecules 2006, 11(12), 978-987; https://doi.org/10.3390/11120978 - 20 Dec 2006

Cited by 11 | Viewed by 8786

Abstract

Tetrahydroquinoline skeletons can be formed by a CuCl₂-catalyzed one-potreaction of N-methyl-N-alkylanilines and vinyl ethers in the presence of t-butyl-hydroperoxide. Full article

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93 KiB

Open AccessArticle

Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

by Li Zhang, Beiying Qiu, Xin Li, Xin Wang, Jingya Li, Yongliang Zhang, Jian Liu, Jia Li and Jingkang Shen

Molecules 2006, 11(12), 988-999; https://doi.org/10.3390/11120988 - 21 Dec 2006

Cited by 13 | Viewed by 10209

Abstract

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay. Full article

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80 KiB

Open AccessArticle

Synthesis and Spectral Investigations of Manganese(II), Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of New Polydentate Ligands Containing a 1,8-Naphthyridine Moiety

by Sreedasyam Jagannatha Swamy, Erra Ram Reddy, Devunuri Naga Raju and Sunkari Jyothi

Molecules 2006, 11(12), 1000-1008; https://doi.org/10.3390/11121000 - 21 Dec 2006

Cited by 20 | Viewed by 8684

Abstract

2-(o-Hydroxyphenyl)-1,8-naphthyridine (HN), 2-(4-hydroxy-6-methylpyran-2-one-3-yl)-1,8-naphthyridine (HMPN) and 2-(benzimidazol-2-yl)-1,8-naphthyridine(BN) react with acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) to yield metal ioncomplexes of definite composition. These compounds were characterized by elementalanalyses, molar conductivity, magnetic susceptibility measurements, thermal studies, IR,UV-visible, NMR and mass spectral investigations. The [...] Read more.

2-(o-Hydroxyphenyl)-1,8-naphthyridine (HN), 2-(4-hydroxy-6-methylpyran-2-one-3-yl)-1,8-naphthyridine (HMPN) and 2-(benzimidazol-2-yl)-1,8-naphthyridine(BN) react with acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) to yield metal ioncomplexes of definite composition. These compounds were characterized by elementalanalyses, molar conductivity, magnetic susceptibility measurements, thermal studies, IR,UV-visible, NMR and mass spectral investigations. The complexes are found to have theformulae [M(HN)₂(H₂O)₂], [M(HMPN)₂(H₂O)₂] and [M(BN)₂(OAc)₂], respectively. Full article

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95 KiB

Open AccessCommunication

A New Neolignan Glycoside from the Leaves of Acer truncatum

by Lang-Ping Dong, Wei Ni, Jin-Yang Dong, Jun-Zhu Li, Chang-Xiang Chen and Hai-Yang Liu

Molecules 2006, 11(12), 1009-1014; https://doi.org/10.3390/11121009 - 21 Dec 2006

Cited by 24 | Viewed by 10419

Abstract

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol 9′-O-β-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-O-α-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1′-benzofuranpropanol (2), schizandriside (3), lyoniresinol (4), berchemol (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), hecogenin (7), chlorogenic acid (8) and neochlorogenic acid (9). Their structures were elucidated [...] Read more.

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol 9′-O-β-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-O-α-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1′-benzofuranpropanol (2), schizandriside (3), lyoniresinol (4), berchemol (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), hecogenin (7), chlorogenic acid (8) and neochlorogenic acid (9). Their structures were elucidated on the basis of extensive spectroscopic data. The absolute configuration of compounds 1 was established by its CD spectrum. The antibacterial activities of compounds 1-7 were evaluated. Full article

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Molecules, Volume 11, Issue 12 (December 2006) – 8 articles , Pages 940-1014

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