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Molecules 2009, 14(10), 3952-3963; doi:10.3390/molecules14103952
Article

An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

, , , , ,  and *
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 116, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 August 2009 / Revised: 25 September 2009 / Accepted: 27 September 2009 / Published: 9 October 2009
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)
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Abstract

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.
Keywords: indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kuo, C.-W.; Wang, C.-C.; Fang, H.-L.; Raju, B.R.; Kavala, V.; Habib, P.M.; Yao, C.-F. An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes. Molecules 2009, 14, 3952-3963.

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