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Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis
Molecules 2009, 14(7), 2337-2344; doi:10.3390/molecules14072337

Selenium and the Methionine Sulfoxide Reductase System

 and *
Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
* Author to whom correspondence should be addressed.
Received: 12 June 2009 / Revised: 26 June 2009 / Accepted: 30 June 2009 / Published: 1 July 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
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Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed.
Keywords: selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oien, D.B.; Moskovitz, J. Selenium and the Methionine Sulfoxide Reductase System. Molecules 2009, 14, 2337-2344.

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