Next Article in Journal
Excitation and Circular Dichroism Spectra of (+)-(S,S)-bis(2-Methylbutyl)chalcogenides
Previous Article in Journal
(6,7-Dimethoxy-4-methylisoquinolinyl)-(4’-methoxyphenyl)-methanone, a New Benzylisoquinoline Alkaloid from Beilschmiedia brevipes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 15
Issue 4
10.3390/molecules15042347
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Boronate Derivatives of Functionally Diverse Catechols: Stability Studies

by
Kamal Aziz Ketuly
* and
A. Hamid A. Hadi
Chemistry Department, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(4), 2347-2356; https://doi.org/10.3390/molecules15042347
Submission received: 27 January 2010 / Revised: 25 February 2010 / Accepted: 22 March 2010 / Published: 31 March 2010
Browse Figures
Versions Notes

Abstract

:
Benzeneboronate of catecholic carboxyl methyl esters, N-acetyldopamine, coumarin and catechol estrogens were prepared as crystalline derivatives in high yield. Related catechol compounds with extra polar functional group(s) (OH, NH2) do not form or only partially form unstable cyclic boronate derivatives.

1. Introduction

The selective reactions of boronic acids with compounds containing two or more suitably disposed proximal polar functional groups (OH, NH, SH, COOH) can afford cyclic derivatives of reduced polarity, of value in analytical characterization and in separation of polyfunctional compounds [1,2]. Crystalline benzeneboronates from the reactions of benzeneboronic acid with polyols [3], sugars [4,5], other carbohydrates [6,7,8], macrolide aglycones [9] and steroids [10] have been isolated and characterized. Depending on the substrates, the condensations could take place in aqueous and aqueous-methanol solutions [3], organic solventc [6], reactions by fusion techniques, or by reaction in anhydrous solvents followed by azeotropic removal of water [5]. Boronate derivatives have a wide range of applications in: separation of isomeric pairs of cis and trans diols [11] and as extracting probes to capture and enrich cis-diol-containing biomolecules [12]; The differences in the solubility of the boronates of isomeric carbohydrates greatly facilitate their separation by fractional re-crystallization [13]; Boronate affinity chromatography (BAC) is an important tool for specific capture and separation of cis-diol-containing compounds such as glycoproteins, RNA and carbohydrates [14]. Systematical investigation on the retention mechanism revealed that multiple intermolecular interactions occur between the analytes and the boronate affinity monolith, including boronate affinity, reversed-phase, cation-exchange and hydrogen bonding interactions, depending on the conditions used [15]; A variety of cyclic boronates that are stable to hydrolysis has been studied by reversed-phase high pressure liquid chromatography (HPLC) [16]. Gas chromatography-mass spectroscopy (GC-MS), of cyclic boronates is valuable and thus relatively highly volatile derivatives of a great variety of the less volatile polar multifunctional compounds, including many of biological importance [17,18,19,20], may be analyzed. Structural information which can be acquired for specific ions, associated with the MS fragmentation of the new functionality, the identification of these, and of other ions containing boron was facilitated by the characteristic isotope ratio of boron (B11:B10, 4:1) [21]; Aryl and heteroaryl boronates are very important intermediates in organic synthesis that have been deployed in many useful transformations [22,23,24] and for the determination of absolute configuration [25]. The rigidity of the cyclic boronate derivatives of corresponding 1,2- or 1,3-diols, requiring relatively fixed conformations, is used in nuclear magnetic resonance (NMR) studies of carbohydrate concentrations and the position of their functional groups [26]. The B11-NMR resonance of boron esters is a broad line and its spectra allow distinction between five, six, seven-member cyclic and acyclic boronates [27,28,29]. Suitable boronate single crystals are useful for X-ray diffraction to establish the conformation and the absolute configuration of the molecule in the crystalline state [22,30,31]. Boronates are used as catalysts, in the complexes of areneboronic acids with carbohydrates, formed in aqueous solution in a manner similar to that of borate [32]. The use of boron-containing compounds in the treatment of cancer has revolved about the unique nuclear property of the non-radioactive B10 isotope with a high cross section to absorb thermal neutrons with the liberation of much energy selectively destroying or weakening cancerous cells [33].
In the present work we focused on the formation and stabilities of cyclic boronate esters of various types of biologically important catechols. Several crystalline cyclic boronate esters of catechols: 3,4-dihydroxy methyl esters 1–4; N-acetyldopamine (5), estra-1,3,5(10)-triene-3,4-diol (6) and 4-methyl-7,8-dihydroxycoumarin (7) were obtained (Table 1), Scheme 1.
Molecules 15 02347 g001 550
Scheme 1. Typical reaction of benzeneboronic acid with catechols.
Scheme 1. Typical reaction of benzeneboronic acid with catechols.
Molecules 15 02347 g001
Table
Table 1. Preparative benzeneboronate derivative formation from catechol type compounds.
Table 1. Preparative benzeneboronate derivative formation from catechol type compounds.
Parent compoundCompound No Amount used mg (mmol)Benzeneboronic acidmg (mmol)Data corresponding benzeneboronates
Amount recovered mg a(% crude yield)m.p. °CMol Formula (Mol. Wt)AnalysisMS
FoundCalc.M+ (%) b
Methyl 3,4-dihydroxybenzoate c 1831629.51050 C14H11BO4C, 65.90C, 66.14254
(4.50)(5.15)(84)109.5-110.5 d(254)H, 4.23H, 4.33(100)
B, 4.78B, 4.3
Methyl -3,4-dihydroxy-phenylacetate 2300203400 C15H11BO4C, 67.20C, 67.16268
(1.65)(1.67)(90.4)82-83 e(268)H, 4.95H, 4.85(97)
B, 3.8B, 4.1
Methyl 3,4-dihydroxydihydro-cinnamate 3500317680 C16H15BO4C, 68.24C, 68.09282
(2.55)(2.6)(95)61-62 f(282)H, 5.38H, 5.32(100)
B, 3.83B, 3.9
Methyl 3,4-dihydroxycinnamate4263170349 C16H13BO4C, 68.7C, 68.57280
(1.36)(1.39)(92)131-133 g(280)H, 4.35H, 4.64(100)
B, 4.01B, 4.0
N-Acetyldopamine59776121405 C16H16BNO3C, 68.0C, 68.33281
(5.01)(5.02)(99.8)159-160 h(281)H, 5.90H, 5.69(6)
B, 4.11B, 3.90
N, 5.06N, 4.98
Estra-1,3,5(10)-triene-3,4-diol i6221028176-177 jC24H27BO2C, 80.42C, 80.45 j358
(0.08)(0.08)(96) (358)H, 7.34H, 7.54(100)
4-Methyl-7,8-dihydroxy-coumarin k7260165370191-193 lC16H11BO4l278
(1.35)(1.35)(98.4) (278) (100)
Notes:
  • a GLC analysis (GC column as in b) of these crude products showed in each case a single peak corresponding to their benzeneboronate derivatives. Traces of excess benzeneboronic acid (eluted as triphenylboroxine) were also observed.
  • b Mass spectral data were recorded at electron energy 20 eV, using an LKB 9000 GC-MS instrument, fitted with a glass column (2 m × 4 mm, i.d.) of 1% OV-1 on Gas Chrom Q (100–120 mesh). The flash heater was at 250 °C, the molecular separator at 270 °C, and ion source at 265 °C. The helium carrier gas flow rate was 30 mL/min. The trap current was 60 mA, filament current 4 A and accelerating voltage 3.5 KV. In Table 1 the abundances for the ion are shown in brackets ( ).
  • c The isomeric methyl 2,3-dihydroxybenzoate did not react fully with benzeneboronic acid, as judged by GLC. On recrystallisation of the crude reaction mixture, from acetone-hexane; the recovered material was largely benzeneboronic acid. Vacuum sublimation of the crude product, also failed to yield any cyclic ester.
  • d Recrystallisation from acetone-hexane; m.p. 107–108.5 °C; then vacuum sublimation: yield a middle fraction which was collected.
  • e Vacuum sublimation at 55 °C/0.01 torr.
  • f Vacuum sublimation at 55 °C/0.01 torr, yielded fine white crystals.
  • g Recrystallisation from acetone-hexane; m.p. 125–127 °C; then followed by vacuum sublimation; a middle fraction was collected.
  • h Vacuum sublimation at 130 °C/torr; m.p. 157–160 °C, a second sublimation yielded fine white crystals.
  • i The isomeric 2-hydroxy-17-deoxoestrone benzeneboronate vacuum sublimation at 140 °C/0.01 torr; yielded a viscous gum, which failed to crystallize from acetone, EtOAc or hexane. Trituration in hexane at low temperature yielded a semi-solid product, which crystallized on standing m.p. 244–247 °C. GC showed traces of benzeneboronic acid. GC-MS, M+358 (100%), a satisfactory micro-analysis or HRMS was not adequate for this compound. This is due to partial hydrolysis on storage. The 1H-NMR showed satisfactory results.
  • j Recrystallisation from acetone; then vacuum sublimation at 160 °C/0.01 torr. The sublimed material was recrystallised twice from acetone. High resolution MS, C24H27BO2, requires 358.2810; found 358.2104.
  • k The isomeric 4-methyl-6,7-dihydroxycoumarin benzeneboronate was formed and showed GC-MS peak with M+ 278 (100%) but attempts to isolate pure crystals were unsuccessful.
  • l Two recrystallisation from CHCl3-hexane, then vacuum sublimation at 140 °C/0.01 torr, gave a middle fraction which was recrystallised from EtOAc-hexane. GLC analysis for this product showed the presence of ca. 0.1% of benzeneboronic acid: the micro-analysis was not satisfactory for carbon. High resolution MS, C16H11BO4, requires 278.0672; found 278.0750.
Molecules 15 02347 g002 550
Figure 2. 1H-NMR, characteristic proton chemical shifts (=ppm), of the catechol-type benzeneboronate derivatives. Data measured in CDCl3 + 0.4% tetramethylsilane, (400 MHz). *
Figure 2. 1H-NMR, characteristic proton chemical shifts (=ppm), of the catechol-type benzeneboronate derivatives. Data measured in CDCl3 + 0.4% tetramethylsilane, (400 MHz). *
Molecules 15 02347 g002

2. Results and Discussion

The compounds in Figure 2, readily prepared under neutral conditions in EtOAc at 70 °C, resulted from the spontaneous reactions of 0.1 molar excess of benzeboronic acid with the catechol group compounds 1–7 in (Table 1).
The recovered crude yields of the cyclic boronates were high (84–99.8%). The esters were stable in anhydrous non-hydroxylic organic solvents (e.g., EtOAc, pyridine, hexane, toluene) and towards aerial oxidation and atmospheric moisture to some extent and remained stable under storage. However, they were unstable on thin-layer chromatography (TLC) or on 'dry column' silica gel chromatography, undergoing disassociation with subsequent partial oxidation. This resulted in hydrolysis of the boronates to their starting materials (the catechol + boronic acid) followed by the aerial oxidation of the catechols to their quinine forms.
The gas chromatography-mass spectrometry (GC-MS) of the benezeneboronates of compounds 1–7 were studied. These results (Table 1) showed that the molecular ions are the base peaks for all the boronate esters, except for compounds (2, 97%) and (5, 6%), [34]. Many of the principal ions in the mass spectra retain boron in their structure. The high resolution mass spectral (HRMS) direct probe for the benzeneboronates of compounds 6 and 7, were measured to confirm their molecular formula (Table 1). The mass spectral fragmentation pattern of the isomeric pairs: 4-methyl-6,7- (and -7,8-)-dihydroxycoumarin and 2- and 4-hydroxy-17-deoxoestrone (estra-1,3,5(10)-triene-3,4-diol), showed no significant differences; but GC succeeded in separating these isomers. In our GC and GC-MS studies of the cyclic boronates, of all the catecholic compounds mentioned in this paper, it has been established that their ease of displacement by acetylating or trimethylsilylating (TMS) reagents allows the application of sequential derivatization procedures. These are the useful features for the analysis of biologically important catechols, which usually exist in low concentrations.
The Infrared spectra of the cyclic boronate derivatives of compounds 1–7 exhibited two characteristic bands, for B-O and Ph-O absorption in the regions 1,325-1,380 cm−1 and 1,390-1,455 cm−1, respectively. The other bands were characteristic for the remaining functional groups of the listed compounds [5,8,35].
The cyclic boronate derivatives of the compounds listed in Figure 2 showed characteristic 1H-NMR chemical shifts for the five aromatic protons of the phenyl group bonded directly to the boron atoms [36,37,38]. The two protons ortho to the boron atom are deshielded, and resonated at δ 8.06–8.87; the two meta protons resonated at higher field, in the region δ 7.47–7.69; whilst the single para proton resonated at δ. 6.55–7.96. The corresponding protons in the catechol boronate unit appeared in the δ 6.72–7.97 region [38,39,40,41], as shown in Figure 2.
The compounds methyl 2,3-dihydroxybenzoate; 2,3-dihydroxybenzaldehyde; 2,3,4-trihydroxy-acetophenone; dopamine; 3-(3,4-dihydroxyphenyl)-L-alanine methyl ester; α-propyldopacetamide; 3,4-dihydroxy-(isopropylamino)acetophenone; salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydro-isoquinoline); 3,4-dihydroxynomifensine; apomorphine; N-n-propylnorapomorphine and 2-hydroxy-estradiol; all formed the cyclic boronate esters, as judged by GC-MS, but these products were not stable and could not be isolated or purified, due to hydrolysis followed by aerial oxidation at ambient temperature. 3,4-Dihydroxy-α-hydroxyphenylacetic acid, tetrahydroxyterephthalic acid diethyl ester, brazilin and gossypol did not yield cyclic boronate derivatives either on an analytical or preparative scale. For some of these compounds, the failure to form stable cyclic boronates may reflect either additional polar functionality or may be due to a reduction in reactivity arising from the strong inter-molecular hydrogen bonding to the catechol hydroxyl groups. Dopamine-3,4-benzeneboronate proved to be highly unstable in air and decomposed to a dark oil. This compound when acetylated yields dopamine triacetate and not compound 13. The benzeneboronate of the isomeric pairs: 2-hydroxy-17-deoxoestrone and 4-methyl-6,7-dihydroxycoumarin were more susceptible to partial hydrolysis on storage than their isomers 14 and 15 respectively. The benzeneboronates of the compounds in (Table 1) are fine crystals and were not suitable for X-ray diffraction structural analysis.

3. Experimental

General

The reagents were obtained from British Drugs House (BDH), except benzeneboronic acid which was from Koch-Light Labs, Ltd. The substrates were obtained from Fluka, BDH, Sigma Chemicals Co., Aldrich Chem. Co., Koch-Light Labs, Ltd. and Makor and the rest were a gift from Professor C.J.W. Brooks (Chemistry Department - Glasgow University). The Infrared (IR) spectra were measured on a Perkin-Elmer Grating Infra Red Spectrophotometer Model 257. The Nuclear Magnetic Resonance (NMR) instrument used was JEOL JNM-LA400, FT NMR System. Spectra were recorded in CDCl3 containing 0.4% tetramethylsilane as internal standard. The mass spectra (direct insertion probe) were measured on a VG MICROMASS 2S8 instrument. Melting points (m.p.) were recorded on a Kofler block.
Methyl esters of acids containing catechol groups1–4: The substrates were refluxed in methanolic HCl [prepared by cautious addition of acetyl chloride (10 mL) to dry methanol (60 mL)] for 4 h, monitored by TLC, and the products were recovered in the normal way.
N-Acetyldopamine (5): This compound was prepared from dopamine by a modification of the procedure of [40]. Dopamine hydrobromide (2.051 g, 8.8 mmol) was dissolved in water (4 mL) and ethyl acetate (20 mL) was added to this solution. A solution of acetic anhydride (0.895 mL, 9.5 mmol) in methanol (20 mL) was added at room temperature. The crude product (1.670 g, 97.7%) was recovered with high yield. This was purified firstly through a short column silica gel and then by vacuum sublimation and a colorless gummy oil was recovered (MS, M+ 195). This product could not be crystallized from different solvent systems and it was sensitive to aerial oxidation. The corresponding benzeneboronate is crystalline, m.p. 159–160 °C (Table 1).
3,4-Dihydroxyestra-1,3,5(10)-triene (6): Firstly, 3-hydroxyestra-1,3,5(10)-triene was prepared from estrone according to a procedure by [42] and this was followed by the procedure of [43] to obtain the isomers: 2,3- and 3,4-dihydroxyestra-1,3,5(10)-triene.
Typical procedure for the preparation of benzeneboronate derivatives: Methyl 3,4-dihydroxy-dihydrocinnamate 3,4-benzeneboronate (11): Methyl 3,4-dihydroxydihydrocinnamate (3, 0.5 g, 2.5 mmol) was dissolved in EtOAc (5 mL); benzeneboronic acid (0.317 g, 2.6 mmol) in EtOAc (2 mL) was added, and the reaction mixture heated for 20 min at 70 °C. After removal of the solvent, the gummy resulting product was dissolved in ether. Evaporation of the solvent with nitrogen yielded a crystalline material (680 mg, 95%), m.p. 60–62 °C. GLC showed a single well-defined peak. Vacuum sublimation yielded fine white crystals, m.p. 61–62 °C. For analytical data and mass spectrometer (MS) are as in Table 1.

4. Conclusions

Stable cyclic benzeneboronate esters of biologically important catechols were formed on a micro-analytical scale and in preparative scale as crystalline products. Some of the catechols with extra polar functional group(s) (OH, NH2) did form cyclic boronates but these were not stable, while others failed to form any cyclic derivatives.

Acknowledgements

Thanks are due to C.J.W. Brooks for providing some of the substrates (Table 1), to John Cole for running the GC-MS and A.L. Ritchie for carrying out the high-resolution MS at the Chemistry Department-Glasgow University. A research scholarship from Glasgow University is greatly acknowledged. The 400 MHz NMR spectrometer used for this project was located at the Department of Chemistry, University of Malaya.

References

  1. Denmark, S.E. Organic Reactions; John Wiley and Sons: Hoboken, NJ, USA, 2009; Volume 73. [Google Scholar]
  2. Hall, D.G. Boronic Acids, Preparation and Application in Organic Synthesis and Medicine; Wiley-VOH Verlag Gmbh & Co. KGaA: Weinheim, German, 2005. [Google Scholar]
  3. Kuivila, H.G.; Keough, A.H.; Obo czenski, E.J. Areneboronates from Diols and Polyols. J. Org. Chem. 1954, 19, 780–783. [Google Scholar] [CrossRef]
  4. Wolfrom, M.L; Solms, J. Phenylboronates of Pentoses and 6-Deoxyhexoses. J. Org. Chem. 1956, 21, 815–816. [Google Scholar] [CrossRef]
  5. Ferrier, R.J. The Interaction of Phenylboronic Acid with Hexosides. J. Chem. Soc. 1961, 2325–2330. [Google Scholar] [CrossRef]
  6. Ferrier, R.J.; Blattner, R.; Field, R.A.; Furneaux, R.H.; Gardiner, J.M.; Hoberg, J.O.; Kartha, K.P.R.; Tilbrook, D.M.C.; Tyler, P.C.; Wightman, R.H. Separatory and Analytical Methods for Sugars. Carbohyd. Chem. 2002, 33, 365–374. [Google Scholar]
  7. Ferrier, R.J.; Prasad, D.; Rudowski, A. Boronic Acid Derivatives as Reagents in Carbohydrate Chemistry. J. Chem. Soc. 1965, 858–863. [Google Scholar]
  8. Yurkevich, A.M.; Dolodkina, I.I.; Varshavskaya, L.S.; Borodulina-shvetz, V.I.; Rudakova, I.P.; Preobrazhenski, N.A. The Reaction of Phenylboronic acid with Nucleosides and Mononucleotides. Tetrahedron 1969, 25, 477–484. [Google Scholar] [CrossRef]
  9. Perun, T.J.; Martin, J.R.; Egan, R.S. Cyclic Phenylboronates as Hydroxyl Protecting Groups in the Synthesis of Monoesters of Macrolide Aglycones. J. Org. Chem. 1974, 39, 1490–1493. [Google Scholar] [CrossRef]
  10. Hungerford, N.L.; McKinney, A.R.; Stenhouse, A.M.; McLeod, M.D. Selective Manipulation of Steroid Hydroxyl Groups with Boronate Esters: Efficient access to Antigenic C-3 linked Steroid-Protein Conjugates and Steroid Sulfate Standards for Drug Detection. Org. Biomol. Chem. 2006, 4, 3951–3959. [Google Scholar] [CrossRef]
  11. Di Luccio, M.; Smith, B.D.; Kida, T.; Borges, C.P.; Alves, T.L.M. Separation of Fructose from a Mixture of Sugars using supported Liquid Membranes. J. Membr. Sci. 2000, 174, 217–224. [Google Scholar] [CrossRef]
  12. Peng, D.; Liang, L.; Jiangang, H.; Zhen, L.; Hong-Yuan, C. Boronate Functionalized Magnetic Nanoparticles and off-line Hyphenation with Capillary Electrophoresis for Specific Extraction and Analysis of Biomolecules Containing cis-Diols. J. Chromatogr.A 2009, 1216, 7558–7563. [Google Scholar]
  13. Yurkevich, A.M.; Kolodkina, I.I.; Varshavskaya, L.S.; Borodulina-shvetz, V.I.; Rudakova, I.P.; Preobrazhenski, N.A. The Reaction of Phenylboronic Acid with Nucleosides and Mononucleotides. Tetrahedron 1969, 25, 477–484. [Google Scholar] [CrossRef]
  14. Liu, X.C.; Scouten, W.H. Studies on Oriented and Reversible immobilization of Glycoprotein using Novel Boronate Affinity Gel. J. Mol. Recognit. 1996, 9, 462–467. [Google Scholar] [CrossRef]
  15. Ren, L.; Liu, Z.; Dong, M.; Ye, M.; Zou, H. Synthesis and Characterization of a Newboronate Affinity Monolithic Capillary for Specific Capture of cis-diol-Containing Compounds. J. Chromatogr. A 2009, 1216, 4768–4774. [Google Scholar]
  16. Gamoh, K.; Ketuly, K. A.; Cole, W.J.; Brooks, C.J.W. Chromatographic and Mass-Spectrometric Studies of Cyclic 2-(N,N-Dimethylaminomethyl)ferroceneboronates and Related Esters. Anal. Sci. 1994, 10, 705–711. [Google Scholar] [CrossRef]
  17. Kiplinger, J.P.; Crowder, C.A.; Catherine, A.; Sorensen, D.N.; Bartmess, J.E. Gas-Phase Ion-Molecule Chemistry of Borate and Boronate Esters. J. Am. Soc. Mass Spectrom. 1994, 5, 169–176. [Google Scholar] [CrossRef]
  18. Smith, A.G.; Brooks, C.J. Gas Chromatography Chemical Ionization Mass Spectrometry of Prostaglandin F Alpha Cyclic Boronate Derivatives. Biomed. Mass Spectrum. 1977, 4, 258–64. [Google Scholar] [CrossRef]
  19. Bullinger, D.; Fux, R.; Nicholson, G.; Plontke, S.; Belka, C.; Laufer, S.; Gleiter, C.H.; Kammerer, B. Identification of Urinary Modified Nucleosides and Ribosylated Metabolites in Humans Via Combined ESI-FTICR MS and ESI-IT MS Analysis. J. Am. Soc. Mass Spectrom. 2008, 19, 1500–1513. [Google Scholar] [CrossRef]
  20. Longstaff, C.; Rose, M.E. Derivatization and Mass Spectrometric Investigations of Substituted Benzeneboronic Acids. The use of linked Scanning during Gas Chromatography Mass Spectrometry. Org. Mass Spectrom. 1982, 17, 508–518. [Google Scholar] [CrossRef]
  21. Brooks, C.J.W.; Middleditch, B.S.; Harvey, D.J. The Mass Spectra of some Corticosteroid Boronates. Org. Mass Specrom. 1971, 5, 1429–1453. [Google Scholar] [CrossRef]
  22. Harrisson, P.; Morris, J.; Marder, T.B.; Steel, P.G. Microwave-Accelerated Iridium-Catalyzed Borylation of Aromatic C−H Bonds. Org. Lett. 2009, 11, 3586–3589. [Google Scholar] [CrossRef]
  23. Simov, B.P.; Wuggenig, F.; Mereiter, K.; Andres, H.; France, J.; Schnelli, P.; Hammerschmidt, F. Direct Chemical Synthesis of Chiral Methanol of 98% ee and Its Conversion to [2H1,3H]Methyl Tosylate and [2H1,3H-Methyl]Methionine. J. Am. Chem. Soc. 2005, 127, 13934–13940. [Google Scholar]
  24. Inglis, S.R.; Woon, E.C.Y.; Thompson, A.L.; Schofield, C.J. Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates. J. Org. Chem. 2010, 75, 468–471. [Google Scholar] [CrossRef]
  25. Resnick, S. M.; Torok, D. S.; Gibson, D.T. Chemoenzymic Synthesis of Chiral Boronates for the Determination of the Absolute Configuration and Enantiomeric Excess of Bacterial and Synthetic cis-Dienediols. J. Org. Chem. 1995, 60, 3546–3549. [Google Scholar] [CrossRef]
  26. van den Berg, R.; Peters, J. A.; van Bekkum, H. The structure and local stability constants of borate esters of mono- and di-sacchrides as studied by 11B and 13C NMR Spectroscopy. Carbohydr. Res. 1994, 253, 1–12. [Google Scholar] [CrossRef]
  27. Ruman, T.; Dlugopolska, K.; Kusnierz, A.; Rode, W. Synthesis and NMR properties of derivatives of 5,6-dihydroborauracil and 5,6-dihydroborathymine. Bioorg. Chem. 2009, 37, 180–184. [Google Scholar] [CrossRef]
  28. Meiland, M.; Heinze, T.; Guenther, W.; Liebert, T. Seven-Membered Ring Boronates at trans-Diol moieties of Carbohydrates. Tetrahedron Lett. 2009, 50, 469–472. [Google Scholar]
  29. Yeste, S.L.; Powell, M.E.; Bull, S.D.; James, T.D. Simple Chiral Derivatization Protocols for 1H NMR and 19F NMRSpectroscopic Analysis of the Enantiopurity of Chiral Diols. J. Org. Chem. 2009, 74, 427–430. [Google Scholar]
  30. Shimanouchi, H.; Saito, N.; Sasada, Y. Crystal and Molecular Structure of N-(p-bromophenyl)-α-D-Ribopyranosylamine 2,4-Cyclic Benzeneboronate. Bull. Chem. Soc. Jap. 1969, 42, 1239–1247. [Google Scholar] [CrossRef]
  31. Wang, A.H.J.; Paul, I.C. Structure of a Derivative of Streptovaricin C Triacetate. Crystal and Molecular Structure of the Atropisomer of the Cyclic p-Bromobenzeneboronate Ester of Streptovaricin C Triacetate: Methylene Dichloride 1:1 Solvate. J. Am. Chem. Soc. 1976, 98, 4612–4619. [Google Scholar] [CrossRef]
  32. Barker, S.A.; Hatt, B.W.; Somers, P.J. Effect of Areneboronic Acids on the Alkaline Conversion of D-glucose into D-fructose. Carbohyd. Res. 1973, 26, 41–53. [Google Scholar] [CrossRef]
  33. Soloway, A.H.; Tjarks, W.; Barnum, B. A.; Rong, F.; Barth, R.F.; Codogni, I.M.; Wilson, J. G. The Chemistry of Neutron Capture Therapy. Chem. Rev. 1998, 98, 1515–1562. [Google Scholar] [CrossRef]
  34. Wiecko, J.; Sherman, W. R. Mass Spectral Study of Cyclic Alkaneboronates of Sugar Phosphates. Org. Mass Spectrom. 2005, 10, 1007–1020. [Google Scholar] [CrossRef]
  35. Butcher, F.K.; Gerrard, W.; Howarthy, M.; Mooney, E.F.; Willis, H.A. The Infrared Spectra of The Aryl Boronate Esters Derived from Catechol and 2:3 Dihydroxynaphthalene. Spectrochimica Acta 1964, 20, 79–95. [Google Scholar] [CrossRef]
  36. Stacey, B.E.; Tierney, B. The use of Boric Acid and Benzeneboronic Acids in the Partial Acetonation of Monosaccharides. Carbohyd. Res. 1976, 49, 129–140. [Google Scholar] [CrossRef]
  37. Gray, C.W.; Walker, B.T.; Foley, R.A.; Houston, T.A. Boronate derivatives of bioactive amines. Tetrahedron Lett. 2003, 44, 3309–3312. [Google Scholar]
  38. Pouchert, C.J.; Campbell, J.R. The Aldrich Library of NMR Sepctra; Adrich Chemical Co.: St. Louis, MO, USA, Vol. IV-VII, K.X., 162.
  39. Nakagawa, T.; Mishima, Y. Title. Kyoto Daigaku genshiro Jikkensho (Tech. Rep.) 1980, KURRI-IR-195, 44–48. [Google Scholar]
  40. Mills, R.R.; Lake, C.R.; Alworth, W.L. Biosynthesis of N-acetyl dopamine by the American cockroach. J. Insect Physiol. 1967, 13, 1539–1546. [Google Scholar] [CrossRef]
  41. Katz, H.E. 18-Anthracenediethynylbis(catechol boronate): A Bidentate Lewis Acid on A Novel Framework. J. Org. Chem. 1989, 54, 2179–2183. [Google Scholar] [CrossRef]
  42. Huang-Minlon, Reaction of Steroid Ketones and other Carbonyl Compounds by Modified Wolff-Kishner Method. J. Am. Chem. Soc. 1949, 71, 3301–3303. [CrossRef]
  43. Gelbke, H.P.; Haupt, O.; Knuppen, R. A Simple Chemical Method of the Synthesis of Catechol Estrogens. Steroids 1972, 21, 205–212. [Google Scholar]
  • Sample Availability: Samples of the compounds are available from the authors.

Share and Cite

MDPI and ACS Style

Ketuly, K.A.; Hadi, A.H.A. Boronate Derivatives of Functionally Diverse Catechols: Stability Studies. Molecules 2010, 15, 2347-2356. https://doi.org/10.3390/molecules15042347

AMA Style

Ketuly KA, Hadi AHA. Boronate Derivatives of Functionally Diverse Catechols: Stability Studies. Molecules. 2010; 15(4):2347-2356. https://doi.org/10.3390/molecules15042347

Chicago/Turabian Style

Ketuly, Kamal Aziz, and A. Hamid A. Hadi. 2010. "Boronate Derivatives of Functionally Diverse Catechols: Stability Studies" Molecules 15, no. 4: 2347-2356. https://doi.org/10.3390/molecules15042347

Article Metrics

Back to TopTop