Next Article in Journal
Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation
Previous Article in Journal
A Practical Synthesis of Betulonic Acid Using Selective Oxidation of Betulin on Aluminium Solid Support
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(10), 11864-11876; doi:10.3390/molecules171011864

Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical Fatigue and Exercise Performance in Mice

Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan
Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
Department of Physical Education, Yuanpei University, Hsinchu 30015, Taiwan
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 6 August 2012 / Revised: 8 September 2012 / Accepted: 8 October 2012 / Published: 9 October 2012
(This article belongs to the Section Natural Products)
Download PDF [2445 KB, uploaded 18 June 2014]


Pumpkin (Cucurbita moschata) is a popular and nutritious vegetable consumed worldwide. The overall purpose of this study was to evaluate the effects of C. moschata fruit extract (CME) on anti-fatigue and ergogenic functions following physiological challenges. Male ICR mice from four groups designated vehicle, CME-50, CME-100 and CME-250, respectively (n = 8 per group in each test) were orally administered CME for 14 days at 0, 50, 100 and 250 mg/kg/day. The anti-fatigue activity and exercise performance were evaluated using exhaustive swimming time, forelimb grip strength, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. The resting muscular and hepatic glycogen was also analyzed after 14-day supplementation with CME. Trend analysis revealed that CME treatments increased grip strength. CME dose-dependently increased 5% body weight loaded swimming time, blood glucose, and muscular and hepatic glycogen levels. CME dose-dependently decreased plasma lactate and ammonia levels and creatine kinase activity after a 15-min swimming test. The mechanism was relevant to the increase in energy storage (as glycogen) and release (as blood glucose), and the decrease of plasma levels of lactate, ammonia, and creatine kinase. Therefore, CME may be potential for the pharmacological effect of anti-fatigue.
Keywords: pumpkin; Cucurbita moschata; anti-fatigue; exercise performance; glycogen pumpkin; Cucurbita moschata; anti-fatigue; exercise performance; glycogen
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, S.-Y.; Huang, W.-C.; Liu, C.-C.; Wang, M.-F.; Ho, C.-S.; Huang, W.-P.; Hou, C.-C.; Chuang, H.-L.; Huang, C.-C. Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical Fatigue and Exercise Performance in Mice. Molecules 2012, 17, 11864-11876.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top