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Molecules 2012, 17(11), 12950-12960; doi:10.3390/molecules171112950
Article

Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba

1, 2, 1, 1 and 1,*
1 Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China 2 Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 21 September 2012 / Revised: 6 October 2012 / Accepted: 19 October 2012 / Published: 1 November 2012
(This article belongs to the Section Natural Products)
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Abstract

Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-N- oxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)- N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines.
Keywords: Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, W.; Hu, J.-F.; Lv, W.-W.; Zhao, Q.-C.; Shi, G.-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules 2012, 17, 12950-12960.

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