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Molecules 2012, 17(11), 13199-13210; doi:10.3390/molecules171113199
Article

Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release

1,2,* , 1, 3, 1 and 1
1 King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia 2 Central Metallurgical Research and Development Institute, CMRDI, Helwan 11421, Cairo, Egypt 3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71111, Egypt
* Author to whom correspondence should be addressed.
Received: 12 September 2012 / Revised: 1 November 2012 / Accepted: 2 November 2012 / Published: 6 November 2012
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Abstract

In this work, mesoporous shells were constructed on solid silica cores by employing anionic surfactante. A co-structure directing agent (CSDA) has assisted the electrostatic interaction between negatively charged silica particles and the negatively charged surfactant molecules. Synthetic parameters such as reaction time and temperature had a significant impact on the formation of mesoporous silica shelld and their textural properties such as surface area and pore volume. Core-mesoporous shell silica spheres were characterized by small angle X-ray scattering, transmission electron microscopy, and N2 adsorption–desorption analysis. The synthesized particles have a uniformly mesoporous shell of 34–65 nm and possess a surface area of ca. 7–324 m2/g, and pore volume of ca. 0.008–0.261 cc/g. The core-mesoporous shell silica spheres were loaded with ketoprofen drug molecules. The in vitro drug release study suggested that core-mesoporous shell silica spheres are a suitable nanocarrier for drug molecules offering the possibility of having control over their release rate.
Keywords: core-shell; mesoporous; anionic surfactant; drug delivery core-shell; mesoporous; anionic surfactant; drug delivery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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El-Toni, A.M.; Khan, A.; Ibrahim, M.A.; Al-Hoshan, M.; Labis, J.P. Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release. Molecules 2012, 17, 13199-13210.

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