Next Article in Journal
Coupling Two Different Nucleic Acid Circuits in an Enzyme-Free Amplifier
Previous Article in Journal
Substituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(11), 13199-13210; doi:10.3390/molecules171113199

Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release

King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
Central Metallurgical Research and Development Institute, CMRDI, Helwan 11421, Cairo, Egypt
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71111, Egypt
Author to whom correspondence should be addressed.
Received: 12 September 2012 / Revised: 1 November 2012 / Accepted: 2 November 2012 / Published: 6 November 2012
Download PDF [620 KB, uploaded 18 June 2014]


In this work, mesoporous shells were constructed on solid silica cores by employing anionic surfactante. A co-structure directing agent (CSDA) has assisted the electrostatic interaction between negatively charged silica particles and the negatively charged surfactant molecules. Synthetic parameters such as reaction time and temperature had a significant impact on the formation of mesoporous silica shelld and their textural properties such as surface area and pore volume. Core-mesoporous shell silica spheres were characterized by small angle X-ray scattering, transmission electron microscopy, and N2 adsorption–desorption analysis. The synthesized particles have a uniformly mesoporous shell of 34–65 nm and possess a surface area of ca. 7–324 m2/g, and pore volume of ca. 0.008–0.261 cc/g. The core-mesoporous shell silica spheres were loaded with ketoprofen drug molecules. The in vitro drug release study suggested that core-mesoporous shell silica spheres are a suitable nanocarrier for drug molecules offering the possibility of having control over their release rate.
Keywords: core-shell; mesoporous; anionic surfactant; drug delivery core-shell; mesoporous; anionic surfactant; drug delivery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

El-Toni, A.M.; Khan, A.; Ibrahim, M.A.; Al-Hoshan, M.; Labis, J.P. Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release. Molecules 2012, 17, 13199-13210.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top