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Molecules 2012, 17(11), 13221-13234; doi:10.3390/molecules171113221

Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

1
Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic
2
Nanotechnology Centre, VSB—Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava, Czech Republic
3
Institute of Chemical Technology, Faculty of Chemical Engineering, Technicka 5, 166 28 Prague 6, Czech Republic
4
Institute of Inorganic Chemistry, Academy of Science, 250 68 Rez, Czech Republic
5
Research Institute for Pharmacy and Biochemistry, Lidicka 1879/48, 602 00 Brno, Czech Republic
Preliminary results were presented at The Sixteenth Electronic Conference on Synthetic Organic Chemistry (ECSOC-16, http://www.sciforum.net/presentation/1008), 1–30 November, 2012 (paper B1008).
*
Authors to whom correspondence should be addressed.
Received: 8 October 2012 / Revised: 31 October 2012 / Accepted: 2 November 2012 / Published: 6 November 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging to class II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whereas 32 samples contained nanoparticles of less than 200 nm. Relationships between solvents and excipients used and their amount are discussed. Based on the results the investigated solvent evaporation methods can be used as an effective and an affordable technique for the preparation of nanoparticles.
Keywords: candesartan cilexetil; atorvastatin; nanoparticles; solvent evaporation; excipients; dynamic light scattering candesartan cilexetil; atorvastatin; nanoparticles; solvent evaporation; excipients; dynamic light scattering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Vaculikova, E.; Grunwaldova, V.; Kral, V.; Dohnal, J.; Jampilek, J. Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation. Molecules 2012, 17, 13221-13234.

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