Next Article in Journal
Radioiodination of Aryl-Alkyl Cyclic Sulfates
Previous Article in Journal
Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(11), 13253-13265; doi:10.3390/molecules171113253

Effects of Taraxacum officinale on Fatigue and Immunological Parameters in Mice

1
Division of Herbal Medicinal Products, Korea Food & Drug Administration (KFDA), Osong Health Technology Administration Complex, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Cheongwon-gun, Chungcheongbuk-do 363-700, Korea
2
College of Pharmacy, Dongduk Women's University, 23-1 Wolgok-dong, Seongbuk-gu, Seoul 136-714, Korea
3
Department of Pharmacology, College of Oriental Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 220-702, Korea
*
Author to whom correspondence should be addressed.
Received: 2 July 2012 / Revised: 18 July 2012 / Accepted: 31 October 2012 / Published: 7 November 2012
Download PDF [586 KB, uploaded 18 June 2014]

Abstract

In Korean herbal medicine dandelion (Taraxacum officinale, TO) has been used to improve energy levels and health. However, the effects of TO in experimental models remain unclear. We examined the anti-fatigue and immune-enhancing effects of TO in mice by performing a forced swimming test (FST) and in vitro by using peritoneal macrophages, respectively. After daily oral administration of TO, blood biochemical parameters related to fatigue were measured after the FST. FST immobility time was significantly decreased in the TO-treated group (100 mg/kg) on the tenth day. TO (10 and 100 mg/kg) treatment significantly increased glucose levels, acting as an energy source. The level of lactic dehydrogenase, which is an accurate indicator of muscle damage, tended to decline after TO administration (10 and 100 mg/kg). When TO (100 mg/kg) was orally administered to mice, blood urea nitrogen levels decreased significantly. We also examined the effect of TO on the production of cytokines and nitric oxide (NO) in mouse peritoneal macrophages. When TO was used in combination with recombinant interferon-gamma (rIFN-γ), a noticeable cooperative induction of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-12p70, and IL-10 production was observed. Furthermore, in peritoneal macrophages, rIFN-γ plus TO treatment significantly increased the production of NO through inducible nitric oxide synthase (iNOS) induction. Taken together, these results suggest that TO improves fatigue-related indicators and immunological parameters in mice.
Keywords: Taraxacum officinale; forced swimming test; mouse peritoneal macrophage; cytokines; nitric oxide Taraxacum officinale; forced swimming test; mouse peritoneal macrophage; cytokines; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, B.-R.; Lee, J.-H.; An, H.-J. Effects of Taraxacum officinale on Fatigue and Immunological Parameters in Mice. Molecules 2012, 17, 13253-13265.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top