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Molecules 2012, 17(12), 13856-13863; doi:10.3390/molecules171213856

An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

1,2,†,* , 2,†, 2 and 3
Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China
Department of Chemistry, Xuzhou Medical College, Xuzhou 221004, China
School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 5 November 2012 / Revised: 17 November 2012 / Accepted: 20 November 2012 / Published: 22 November 2012
(This article belongs to the Section Organic Synthesis)
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A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed. View Full-Text
Keywords: pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhu, S.; Wang, J.; Xu, Z.; Li, J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules 2012, 17, 13856-13863.

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