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Molecules 2012, 17(12), 14249-14259; doi:10.3390/molecules171214249
Article

Recent Developments in the Reformatsky-Claisen Rearrangement

*  and
Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
* Author to whom correspondence should be addressed.
Received: 8 November 2012 / Revised: 21 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
(This article belongs to the Special Issue Claisen Rearrangement)
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Abstract

The rearrangement of allyl a-bromoacetates with Zn dust is known as the Reformatsky-Claisen rearrangement. Whereas the Ireland-Claisen rearrangement has been widely used in the synthesis of a diverse range of natural products, the Zn-mediated Reformatsky-Claisen rearrangement has not been utilized so often. In this article, we will provide an overview of recent advances in the Reformatsky-Claisen rearrangement field, including the In-mediated Reformatsky-Claisen rearrangement we have recently developed.
Keywords: Reformatsky-Claisen rearrangement; Reformatsky reaction; Claisen rearrangement; zinc; indium Reformatsky-Claisen rearrangement; Reformatsky reaction; Claisen rearrangement; zinc; indium
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ishihara, J.; Hatakeyama, S. Recent Developments in the Reformatsky-Claisen Rearrangement. Molecules 2012, 17, 14249-14259.

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