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Molecules 2012, 17(12), 14288-14297; doi:10.3390/molecules171214288

A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists

Department of Biochemical Engineering, Nanjing University Science & Technology, Chemical Engineering Building B302, 200 Xiaolinwei, Nanjing 210094, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 6 November 2012 / Revised: 27 November 2012 / Accepted: 28 November 2012 / Published: 3 December 2012

Abstract

A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.
Keywords: loperamide analogs; μ opioid receptor agonist; morphine; opioid ligand receptors loperamide analogs; μ opioid receptor agonist; morphine; opioid ligand receptors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bao, X.; Liu, D.; Jin, Y.; Yang, Y. A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists. Molecules 2012, 17, 14288-14297.

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