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Molecules 2012, 17(12), 14899-14907; doi:10.3390/molecules171214899

Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells

1
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
2
School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China
*
Author to whom correspondence should be addressed.
Received: 9 November 2012 / Revised: 29 November 2012 / Accepted: 30 November 2012 / Published: 13 December 2012
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Abstract

Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 17 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
Keywords: Platycodon grandiflorum; oleanane-type triterpenoid; triterpenoid saponin Platycodon grandiflorum; oleanane-type triterpenoid; triterpenoid saponin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhan, Q.; Zhang, F.; Sun, L.; Wu, Z.; Chen, W. Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells. Molecules 2012, 17, 14899-14907.

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