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Article

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

by
Hanadi Y. Medrasi
1,
Mariam Abdullah Al-Sheikh
1,* and
Abdellatif Mohamed Salaheldin
2
1
Department of Chemistry, Sciences faculty for Girls, King AbdulAziz University, Jeddah, P.O. Box 13343, Jeddah 21493, Saudi Arabia
2
Department of Chemistry, College of Applied Sciences, Umm Al-Qura University, P.O. Box 13401, Makkah 21955, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(1), 535-544; https://doi.org/10.3390/molecules18010535
Submission received: 29 October 2012 / Revised: 15 November 2012 / Accepted: 24 December 2012 / Published: 2 January 2013
(This article belongs to the Section Organic Chemistry)

Abstract

:
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.

1. Introduction

The synthesis and chemistry of 4-aminopyrazole-5-carboxylic acid derivatives is now receiving considerable interest [1,2,3,4]. Potential applications in pharmaceutical industry are most likely behind this interest. For example, ethyl 3-butyl-4-aminopyrazole-5-carboxylate is a key intermediate in synthesis of Viagra (Figure 1) [5,6] while 5-aminopyrazole-4-carboxamide is the building block for the synthesis of allopurinol (Figure 1). 4-Aminopyrazoles has been generally prepared via nitration of pyrazoles and subsequent reduction of the formed 4-nitropyrazole but such approach requires discarding large amounts of hazardous acid waste [1,2], which could be minimized as recently reported [7]. The ring transformation reaction of 1,2,4,5-tetrazines to 4-aminopyrazoles by cyanotrimethylsilane (TMSCN) [8]; addition of nitrile imines to benzo-1,4-oxazines [9] or reaction of ethyl diazoacetate with benzyl cyanide are alternate routes to 4-aminopyrazoles [10], but again these either utilize explosive starting materiales or rather expensive ones. A route to 4-aminopyrazoles via a Gabriel-like synthesis has also been recently reported, but this approach is not atom economic and also employs expensive dimethylformamide dimethylacetal (cf. Scheme 1) [11].
Figure 1. Structure of Viagra and Allopurinol.
Figure 1. Structure of Viagra and Allopurinol.
Molecules 18 00535 g001
Scheme 1. Literatures preparation of 4-aminopyrazole derivatives.
Scheme 1. Literatures preparation of 4-aminopyrazole derivatives.
Molecules 18 00535 g002
Microwave-assisted reactions have received great interest in synthetic organic chemistry. Microwave heating has been employed as a frequent resource for improvement of classical reactions. The major benefits of performing reactions under microwave condition are: shorter reaction times, ease of isolation of the products after easy work-up, significant rate enhancements and higher product yields as compared to reactions run under conventional heating [12,13,14].

2. Results and Discussion

In conjunction to our interest in chemistry of pyrazoles [15,16,17] and condensed pyrazoles [18,19,20] we decided to develop an efficient route to the title compounds. A logical route to these compounds would be the reaction of hydrazones 1a,f with functionally substituted alkyl halides to yield targeted compounds 3 via intermediate 2. Although 1ac can be readily obtained from reaction of 4 with cyanide ion following a procedure similar to that described earlier [21], this approach was discarded based on the apparent hazards. We firstly considered the reaction of aldehyde hydrazones 5 as a route to 6 that can then be converted to 1 via reaction with hydroxylamine in a microwave oven as has been recently reported from our laboratories. However, under such conditions cinnolines 7 [18] were the only products obtained (cf. Scheme 2).
Scheme 2. Preparation of 4-aminopyrazoles.
Scheme 2. Preparation of 4-aminopyrazoles.
Molecules 18 00535 g003
The methylene group in p-nitrobenzylcyanide (8a) was sufficiently acidic to couple directly with benzenediazonium chlorides to yield 1ac and thus initial conversion into enamine was not needed. Condensation of 8a with dimethylformamide dimethylaceteal (DMFDMA) under reflux for 3 h. produced 9a in 70% yield.
Trials to condense benzyl cyanide (8b) with DMFDMA to obtain 9b failed, as the volatility of the reagent did not allow for the use of high reaction temperatures. Consequently we decided to generate less volatile formamide acetals in situ thus allowing for employing higher temperatures. We could thus successfully prepare 11a,b via refluxing triethyl orthoformate, piperidine or morpholine with benzyl cyanide in dimethylformamide solution under reflux for 72 h. (cf. Scheme 3) [22]. Although it is possible that the initially formed ethoxyacrylonitrile (11c) reacted with the secondary amine, this possibility could be readily excluded as benzyl cyanide failed to condense with triethyl orthoformate under reflux with DMF in the absence of secondary amine. We thus believe that the acetals 10a,b are initially formed and then these react with benzyl cyanide to yield 11a,b. This condensation could be effected by microwave heating for 20 min to obtain 11a,b, and were found identical in all details (melting point and TLC analysis, NMR) to the compounds obtained under conventional heating.
We have decided to test the possibility that enaminonitriles 11 can couple with aromatic diazonium salts to yield intermediates 12 that would be readily converted into 13 and consequently into 1df [23] via a Japp-Klingmann cleavage [24], a similar coupling process that has been previously reported by us [15].
Scheme 3. Preparation of hydrazones 1af.
Scheme 3. Preparation of hydrazones 1af.
Molecules 18 00535 g004
Enaminonitriles 1 were found to be good candidates to obtain 4-aminopyrazoles based on a Thorpe-Ziegler cyclization [25,26]. In this method, N-alkylation of enaminonitrile was carried out using α-haloketones in anhydrous DMF in the presence of K2CO3 as the base. Moreover, compounds having an aryl substituent on the amino moiety of the enamine group were the most convenient for alkylation and spontaneous intramolecular cyclization. The presence of this group facilitates the formation of the N-anion required for alkylation and subsequent carbanion formation for the cyclization involving the cyano group. The reaction of enaminonitrile 1 with chloroacetonitrile, chloroacetone, ethyl bromoacetate and α-bromoacetophenone in DMF/K2CO3 afforded the corresponding 4-aminopyrazole derivatives 3ae in low yield (27–44%) via intermediate 2. We prepared compound 3 by a modification of the method used by Gewald et al. [24,25] using triethylamine as base. When the reaction was carried out in an excess of triethylamine solution, the desired 4-aminopyrazole derivatives 3ae are obtained in a satisfactory yield (77–92%).
The structure of compounds 3aewas established on the basis of elemental analysis, IR, mass, 1H and 13C-NMR spectral data studies (cf. Experimental Section). For example, the 1H-NMR spectrum of compound 3a showed the absence of a signal for a methylene function and the presence of a two proton D2O-exchangeable signal at δ = 6.45 ppm for the amino function and the aromatic protons in the proper positions. 13C-NMR and mass spectra of compound 3a are in agreement with the proposed structure. This synthesis thus opens a new route for synthesis of 4-aminopyrazole-5-carbonitriles; important intermediates in synthesis of pharmaceuticals (e.g., Viagra). The scope of this synthetic approach is being now explored.

3. Experimental

3.1. General

All melting points are uncorrected. IR spectra were recorded in KBr with a Bruker Vector 22 (Ettlingen, Germany) spectrophotometer. The 1H-NMR (300 MHz) and 13C-NMR (75.4 MHz) spectra were recorded on a Varian Mercury 300 MHz spectrometer in DMSO-d6 as solvent and TMS as internal standard; chemical shifts are reported in δ units (ppm). Mass spectra were measured at 70 eV using a Shimadzu GCMS-QP-1000 EX mass spectrometer. Microanalyses were performed on a LECO CHN-932 by the Microanalysis Unit of Cairo University. Microwave experiments were conducted in aCEM MARS oven.

3.2. Preparation of Substituted Aryl Hydrazonoacetonitriles 1a–f

A cold solution of aryldiazonium salt (10 mmol) was prepared by adding a solution of sodium nitrite (10 mmol in H2O) to a cold solution of the aromatic amine hydrochloride with stirring. The resulting solution of the aryldiazonium salt was added to a cold solution of p-nitrobenzylcyanide (8a, 1.62 g, 10 mmol), 2-phenyl-3-piperidin-1-yl-acrylonitrile (11a) or 3-morpholin-4-yl-2-phenyl-acrylonitrile (11b) in ethanol (50 mL) containing sodium acetate (5 g). The reaction mixture was stirred at room temperature for 30 min. The solid product, so formed, was collected by filtration, washed with water and crystallized from the appropriate solvent.
4-Nitrophenyl(phenylhydrazono)acetonitrile (1a). Yield 70%. m.p. 200–201 °C (lit. m.p. = 198 °C [23]). IR: ν = 3380 (NH), 2208 (CN), 1463, 1376 (NO2) cm−1. 1H-NMR: δ = 6.99–7.25 (m, 5-H, Ar-H), 7.30 (s, 1H, NH), 7.75 (d, 2H, J = 10 Hz, Ar-H), 8.22 (d, 2H, J = 10 Hz, Ar-H). 13C-NMR: δ = 157.2 (C=N), 155.2, 144.1, 137.4, 130.2, 129.1, 124.5, 123.4, 120.2, 117.2 (CN). MS (EI): m/z (%) = 266 (M+, 89%). Anal. Calcd. for C14H10N4O2 (266.25): C, 63.15; H, 3.79; N, 21.04. Found: 63.05; H, 3.80; N, 21.10.
(4-Chlorophenyl)hydrazono(4-nitrophenyl)acetonitrile (1b). Yield 79%. m.p. 225–227 °C. IR: ν = 3395 (NH), 2218 (CN), 1460, 1372 (NO2) cm−1. 1H-NMR: δ = 6.80 (d, 2H, J = 9.5 Hz, Ar-H), 7.20 (d, 2H, J = 9.5 Hz, Ar-H), 7.35 (s, 1H, NH), 7.56 (d, 2H, J = 10 Hz, Ar-H), 8.29 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 300 (M+, 65%). Anal. Calcd. for C14H9ClN4O2 (300.70) C, 55.92; H, 3.02; Cl, 11.79; N, 18.63. Found: 55.80; H, 3.00; Cl, 11.90; N, 18.55.
(4-Nitrophenyl)-(4-nitrophenyl)hydrazonoacetonitrile (1c). Yield 75%. m.p. 235–236 °C. IR: ν = 3385 (NH), 2220 (CN); 1466, 1379 (NO2) cm−1. 1H-NMR: δ = 6.90 (d, 2H, J = 10 Hz, Ar-H), 7.10 (s, 1H, NH), 7.65 (d, 2H, J = 10 Hz, Ar-H), 7.86 (d, 2H, J = 10 Hz, Ar-H), 8.15 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 311 (M+, 87%). Anal. Calcd. for; C14H9N5O4 (311.25): C, 54.02; H, 2.91; N, 22.50. Found: C, 53.90; H, 2.80; N, 22.45.
Phenyl(phenylhydrazono)acetonitrile (1d). Yield 68%, m.p. 100–102 °C. IR: ν = 3360 (NH), 2210 (CN) cm−1. 1H-NMR: δ = 6.99–7.25 (m, 5-H, Ar-H), 7.30 (s, 1H, NH), 7.40–7.62 (m, 5-H, Ar-H). MS (EI): m/z (%) = 221 (M+, 89%). Anal. Calcd. for C14H11N3 (221.26): C, 76.00; H, 5.01; N, 18.99. Found: 75.90; H, 5.10; N, 19.05.
(4-Chlorophenyl)hydrazonophenyl acetonitrile (1e). Yield 82%, m.p. 180–182 °C (lit. m.p. = 168 °C [23]). IR: ν = 3360 (NH), 2215 (CN) cm−1. 1H-NMR: δ = 7.00 (d, 2H, J = 10 Hz, Ar-H), 7.18 (d, 2H, J = 10 Hz, Ar-H), 7.28 (s, 1H, NH), 7.35–7.65 (m, 5-H, Ar-H). MS (EI): m/z (%) = 255 (M+, 81%). Anal. Calcd. for C14H10ClN3 (255.70): C, 65.76; H, 3.94; Cl, 13.86; N, 16.43. Found: C, 65.70; H, 3.80; Cl, 13.90; N, 16.55.
(4-Nitrophenyl)hydrazonophenylacetonitrile (1f). Yield 77%, m.p. 212–214 °C (lit. m.p. = 214 °C [23]). IR: ν = 3385 (NH), 2220 (CN) 1460, 1372 (NO2) cm−1; 1H-NMR: δ = 6.95 (d, 2H, J = 10 Hz, Ar-H), 7.07 (s, 1H, NH), 7.25–7.68 (m, 5H, Ar-H), 7.92 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 266 (M+, 91%). Anal. Calcd. for C14H10N4O2 (266.25): C, 63.15; H, 3.79; N, 21.04. Found: C, 63.20; H, 3.85; N, 21.15.

3.3. General Procedure for Preparation of 4-Aminopyrazole Derivatives 3a–e

Method A. A mixture of 1a,f (0.01 mol), the α-halo compound (chloroacetonitrile, chloroacetone, ethyl bromoacetate and α-bromoacetophenone, 0.011 mol), and potassium carbonate (2.0 g) in dimethylformamide (20 mL) was stirred for 1 h, at 90 °C, in an oil-bath. The reaction mixture was cooled and poured into water (60 mL). The precipitated solid products formed were filtered off, washed thoroughly with cold water and recrystallized from EtOH to afford the corresponding cyclized products 3a (40 %), 3b (47%), 3c (39%), 3d (35%), 3e (22%).
Method B. To a solution of the intermediate 1a,f (0.01 mol) the α-halo compound (chloroacetonitrile, chloroacetone, ethyl bromoacetate and α-bromoacetophenone, 0.011 mol) and triethylamine (4 mL) were added with external cooling. The reaction mixture was refluxed for 20–30 min, after cooling (50 mL) water was added, the solid product was filtered off, washed thoroughly with cold water and crystallized from ethanol (in the case of 3a, 88%, 3b, 92). For derivatives 3ce a brown oil was separated, the water was decanted and the oil was extracted with CH2Cl2 (3 × 25 mL) and the combined organic layers were dried (Na2SO4), filtered and the solvent was evaporated to give a solid which was crystallized from EtOH.
4-Amino-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-5-carbonitrile (3a). Yield 88%, m.p. 187–188 °C; IR: ν = 3310–3250 (NH2), 2224 (CN), 1463, 1375 (NO2) cm−1; 1H-NMR: δ = 6.45 (s, 2H, NH2), 7.25–7.38 (m, 5H, Ar-H), 7.62 (d, 2H, J = 10 Hz, Ar-H), 8.10 (d, 2H, J = 10 Hz, Ar-H); 13C-NMR: δ = 98.98 (C-5), 113.23 (CN), 116.13 (C-2′, 6′), 123.38 (C-3′′, 5′′), 123.71 (C-4′), 129.38 (C-2′′, 6′′), 129.82 (C-3′, 5′), 140.05 (C-1′), 144.77 (C-1′′), 145.23 (C-3), 146.90 (C-4), 147.65 (C-4′′). MS (EI): m/z (%) = 305 (M+, 100%). Anal. Calcd. for C16H11N5O2 (305.): C, 62.95; H, 3.63; N, 22.94. Found: C, 63.10; H, 3.85; N, 23.05.
4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazole-5-carbonitrile (3b). Yield 92%, m.p. 178–180 °C IR: ν = 3320–3240 (NH2), 2228 (CN) 1466, 1369 (NO2) cm−1, 1H-NMR: δ = 6.49 (s, 2H, NH2), 7.25–7.48 (m, 5H, Ar-H), 7.55 (d, 2H, J = 10 Hz, Ar-H), 8.20 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 305 (M+, 85%). Anal. Calcd. for C16H11N5O2 (305): C, 62.95; H, 3.63; N, 22.94. Found: C, 63.10; H, 3.85; N, 23.05. Found: C, 63.00; H, 3.65; N, 22.80.
Ethyl 4-amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (3c). Yield (74%), m.p. 165–166 °C; IR: ν = 3492–3380 (NH2), 1715 (C=O) cm−1. 1H-NMR: δ = 0.98 (t, 3H, J = 7.5Hz, CH3), 4.04 (q, 2H, J = 7.5 Hz, CH2), 5.94 (s, 2H, NH2), 7.21 (d, 2H, J = 9 Hz, Ar-H), 7.28 (t, 1H, J = 8 Hz, Ar-H), 7.31–7.39 (m, 4H, Ar-H), 8.14 (d, 2H, J = 9 Hz, Ar-H). 13C-NMR: δ = 14.12 (CH3), 59.10 (CH2), 108.72 (C-5), 113.53 (C-3′,5′), 121.23 (C-2′′,6′′), 127.21 (C-2′,6′), 127.94 (C-4′′), 132.14 (C-1′), 132.92 (C-3′′,5′′), 137.31 (C-1′′), 141.96 (C-3), 146.41 (C-4), 150.86 (C-4′), 160.32 (C=O). MS (EI): m/z (%) = 352 (M+, 77%). Anal. Calcd. For C18H16N4O4 (352.12): C, 61.36; H, 4.58; N, 15.90. Found C, 61.55; H, 4.42; N, 16.12.
1-(4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazol-5-yl)ethanone (3d). Yield: 77%, m.p. 192–193 °C. IR: ν = 3440–3348 (NH2), 1678 (C=O) cm−1. 1H-NMR: δ = 2.23 (s, 3H, CH3), 6.67 (s, 2H, NH2), 7.09 (t, 1H, J = 9 Hz, Ar-H), 7.36 (d, 2H, J = 9 Hz, Ar-H), 7.42–7.55 (m, 4H, Ar-H), 8.23 (d, 2H, J = 9 Hz, Ar-H). 13C-NMR: δ = 28.52 (CH3), 114.28 (C-3′,5′), 118.20 (C-5), 122.12 (C-2′′,6′′), 127.93 (C-2′,6′), 128.51 (C-4′′), 132.21 (C-1′), 133.62 (C-3′′,5′′), 138.64 (C-1′′), 143.31 (C-3), 147.45 (C-4), 149.38 (C-4′), 186.21 (C=O). MS (EI): m/z (%) = 332 (80) [M]+. Anal. Calcd. For C17H14N4O3 (322.32): C, 63.35; H, 4.38; N, 17.38. Found C, 63.49; H, 4.17; N, 17.15.
(4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazol-5-yl)(phenyl)methanone (3e). Yield: 72%; m.p. 224–226 °C. IR: ν = 3452–3367 (NH2), 1690 (C=O) 1465, 1372 (NO2) cm−1. 1H-NMR: δ = 6.58 (s, 2H, NH2), 7.14 (d, 2H, J = 9 Hz, Ar-H), 7.20–7.26 (m, 4H, Ar-H), 7.30–7.38 (m, 6H, Ar-H), 8.12 (d, 2H, J = 9 Hz, Ar-H). MS (EI): m/z (%) = 384 (42) [M]+. Anal. Calcd. For C22H16N4O3 (384.39): C, 68.74; H, 4.20; N, 14.58. Found C, 68.60; H, 4.44; N, 14.70.

3.4. 3-Dimethylamino-2-(4-nitrophenyl) acrylonitrile (9a)

A mixture of 8a (0.01 mol) and DMFDMA (0.012 mol) in dioxane (15 mL) was refluxed for three hours then cooled and poured onto water. The green solid product, so formed, was collected by filtration and crystallized from ethanol to give 9a. Yield 70%; m.p. 178–180 °C. IR: ν = 2222 (CN), 1610 (C=C) cm−1. 1H-NMR: δ = 3.27 (s, 3H, CH3), 3.33 (s, 3H, CH3), 7.50 (d, 2H, J = 9Hz, Ar-H), 7.80 (s, 1H, olefinic-H), 8.12 (d, 2H, J = 9Hz, Ar-H). 13C-NMR: δ = 43.64 (2CH3), 97.27 (C=CH), 122.54 (CN), 123.36, 132.40, 144.45, 145.75, 150.50 (C=CH). MS (EI): m/z (%) = 217 (100) [M+]. Anal. Calcd. For C11H11N3O2 (217.22): C, 60.82, H, 5.10, N, 19.34. Found C, 60.85, H, 5.03, N, 19.30.

3.5. 3-Substituted Amino-2-phenylacrylonitriles 11a,b

Method A. To a mixture of benzyl cyanide 8b (0.3 mol), triethyl orthoformate (0.32 mol), and piperidine or morpholine (0.3 mol each) DMF (40 ml) was added and the solution was refluxed for 72 h. The reaction mixture was then cooled and poured onto water. The solid product formed, was collected by filtration and crystallized from ethanol, (11a 70%; 11b 65%).
Method B. Under Microwave irradiation. In a round bottom flask of 100 mL equipped with a condenser, benzyl cyanide 8b (0.3 mol), triethyl orthoformate (0.32 mol), and piperidine or morpholine (0.3 mol each) DMF (40 ml) was added and the mixture was heated at reflux during 20 min under microwave irradiation (at a constant power of 400 W). After cooling to r.t., the reaction mixture was poured onto water to give a solid, which was identical in all respects with that obtained from the above reactions (TLC, m.p., NMR), (11a 85%; 11b 77%).
2-Phenyl-3-piperidin-1-yl-acrylonitrile (11a). Yield: 85%, m. p. 116–117 °C. IR: ν = 2190 (CN), 1616 (C=C) cm−1. 1H-NMR: δ = 1.60 (s, 6H, 3CH2), 3.63 (s, 4H, 2CH2), 7.16 (s, 1H, olefinic-H), 7.26–7.45 (m, 5 H, Ar-H). 13C-NMR: δ = 24.36, 26.41, 51.96, 75.41 (C=CH), 121.59 (CN), 124.48, 125.51, 129.14, 137.27, 149.29 (C=CH). MS (EI): m/z (%) = 212 (42) [M+]. Anal. Calcd. For C14H16N2 (212.29): C, 79.21, H, 7.60, N, 13.20. Found C, 79.29, H, 7.67, N, 13.17.
3-Morpholin-4-yl-2-phenyl-acrylonitrile (11b). Yield 77%, m.p. 105–106 °C; IR: ν = 2205 (CN), 1620 (C=C). 1H-NMR: δ = 2.85 (t, 4H, 2CH2), 3.75 (t, 4H, 2CH2), 6.92 (s, 1H, olefinic-H), 7.15–7.39 (m, 5H, Ar-H). MS (EI): m/z 214 (M+, 93%). Anal. Calcd. For C13H14N2O2 (214.): C, 72.87; H, 6.59; N, 13.07. Found: C, 72.80; H, 6.55; N, 13.10.

4. Conclusions

Enaminonitriles could be easily obtained by reaction of benzyl cyanide or 4-nitrobenzyl cyanide with DMFDMA or with triethylorthoformate and piperidine or morpholine in the presence of DMF, in situ generation of less volatile amide acetals from piperidine diethylacetal would enable avoiding the application of drastic reaction conditions in the condensation of amide acetals with active methylenes, thus further application of condensation reaction to less reactive methylenes can be applied. This method involves the of less expensive chemicals and conversion of methylenes to enamines enhances reactivity toward electrophiles. Shorter reaction times and higher yields were obtained by microwave irradiation.

Acknowledgments

We are grateful to E.A. Hafez for continued help and critical comments on our research progress.
  • Sample Availability: Samples of the compounds 1af, 9a and 11a,b are available from the authors.

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MDPI and ACS Style

Medrasi, H.Y.; Al-Sheikh, M.A.; Salaheldin, A.M. Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives. Molecules 2013, 18, 535-544. https://doi.org/10.3390/molecules18010535

AMA Style

Medrasi HY, Al-Sheikh MA, Salaheldin AM. Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives. Molecules. 2013; 18(1):535-544. https://doi.org/10.3390/molecules18010535

Chicago/Turabian Style

Medrasi, Hanadi Y., Mariam Abdullah Al-Sheikh, and Abdellatif Mohamed Salaheldin. 2013. "Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives" Molecules 18, no. 1: 535-544. https://doi.org/10.3390/molecules18010535

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