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Molecules 2013, 18(1), 814-831; doi:10.3390/molecules18010814

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

1
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Received: 26 November 2012 / Revised: 4 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Organic Synthesis)
Download PDF [318 KB, 18 June 2014; original version 18 June 2014]

Abstract

An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process involving formation of two new C–N bonds and one new C–O bond.
Keywords: silver; one-pot; cascade transformation; isoquinolines; heterocyclic molecule silver; one-pot; cascade transformation; isoquinolines; heterocyclic molecule
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jiang, B.; Zhou, Y.; Kong, Q.; Jiang, H.; Liu, H.; Li, J. ‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach. Molecules 2013, 18, 814-831.

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