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Molecules 2013, 18(1), 832-844; doi:10.3390/molecules18010832

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

1
Organic Synthetic Lab, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt
2
Department of Chemistry, Faculty of Science, Taif University, Taif 21974, Saudi Arabia
Present address: Chemistry Department, Faculty of Science, Cairo University, Cairo 12613, Egypt.
*
Author to whom correspondence should be addressed.
Received: 31 October 2012 / Revised: 4 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the precursor hydrazone towards hydrazine derivatives to give pyrazole and oxazole derivatives was studied. On the other hand, treatment of the same precursor with urea, thiourea and/or guanidine hydrochloride furnished pyrimidine and thiazine derivatives, respectively. The newly synthesized compounds were tested for antibacterial activity, whereby eight compounds were found to have high activities.
Keywords: cyanoacetylhydrazide; sulfonamide; pyridazines; pyrazoles; oxazole; pyrimidines; antibacterial activity cyanoacetylhydrazide; sulfonamide; pyridazines; pyrazoles; oxazole; pyrimidines; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Azab, M.E.; Youssef, M.M.; El-Bordany, E.A. Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety. Molecules 2013, 18, 832-844.

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