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Molecules 2013, 18(1), 934-950; doi:10.3390/molecules18010934

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro

1
Department of Oncology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China
2
Department of General Surgery, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China
3
Department of Pharmacology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 22 December 2012 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Natural Products)
Download PDF [831 KB, 18 June 2014; original version 18 June 2014]

Abstract

Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.
Keywords: hepatoma; Scutellaria barbata; invasion; metastasis; matrix metalloproteinase hepatoma; Scutellaria barbata; invasion; metastasis; matrix metalloproteinase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dai, Z.-J.; Wang, B.-F.; Lu, W.-F.; Wang, Z.-D.; Ma, X.-B.; Min, W.-L.; Kang, H.-F.; Wang, X.-J.; Wu, W.-Y. Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro. Molecules 2013, 18, 934-950.

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