Next Article in Journal
Beads-Based Electrochemical Assay for the Detection of Influenza Hemagglutinin Labeled with CdTe Quantum Dots
Next Article in Special Issue
Influence of Temperature on the Enantioselectivity of Koga Tetraamines on Amylose Chiral Stationary Phases
Previous Article in Journal
Synthesis of δ-Oxo-1,1-bis(triflyl)alkanes and Their Acidities
Previous Article in Special Issue
Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame
Article Menu

Export Article

Open AccessReview
Molecules 2013, 18(12), 15541-15572; doi:10.3390/molecules181215541

Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones

Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, complesso universitario di Monserrato, S.S. 554, bivio per Sestu, Monserrato 09042, CA, Italy
*
Author to whom correspondence should be addressed.
Received: 7 November 2013 / Revised: 9 December 2013 / Accepted: 11 December 2013 / Published: 13 December 2013
(This article belongs to the Special Issue Dynamic Stereochemistry)

Abstract

In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013.
Keywords: cyclobutanone; cyclobutane; stereocontrol; ring enlargement; alkylation; organocatalysis; cycloaddition; biocatalysis; stereochemistry; oxidation cyclobutanone; cyclobutane; stereocontrol; ring enlargement; alkylation; organocatalysis; cycloaddition; biocatalysis; stereochemistry; oxidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Secci, F.; Frongia, A.; Piras, P.P. Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones. Molecules 2013, 18, 15541-15572.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top