Next Article in Journal
Anti-Mycobacterial Activity of Marine Fungus-Derived 4-Deoxybostrycin and Nigrosporin
Previous Article in Journal
Chemical Genetics of Acetyl-CoA Carboxylases
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(2), 1720-1727; doi:10.3390/molecules18021720

Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke

1
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China
*
Author to whom correspondence should be addressed.
Received: 19 December 2012 / Revised: 18 January 2013 / Accepted: 18 January 2013 / Published: 29 January 2013
Download PDF [259 KB, uploaded 18 June 2014]

Abstract

Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 14) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 13 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala.
Keywords: Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tian, X.; Ding, G.; Peng, C.; Hu, Y.; Li, L.; Chen, H.; Zou, Z. Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke. Molecules 2013, 18, 1720-1727.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top