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Molecules 2013, 18(2), 1985-1994; doi:10.3390/molecules18021985
Article

Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines

1, 1,* , 1, 2 and 3
1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia 2 Faculty of Medicine and Health Science, Universiti Tunku Abdul Rahman, Kajang 43000, Selangor, Malaysia 3 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 17 December 2012 / Revised: 16 January 2013 / Accepted: 22 January 2013 / Published: 4 February 2013
(This article belongs to the Section Natural Products)
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Abstract

The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
Keywords: cytotoxicity; Mesua beccariana; Mesua ferrea; Mesua congestiflora; structure-activity relationship; xanthones cytotoxicity; Mesua beccariana; Mesua ferrea; Mesua congestiflora; structure-activity relationship; xanthones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Teh, S.S.; Ee, G.C.L.; Mah, S.H.; Lim, Y.M.; Ahmad, Z. Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines. Molecules 2013, 18, 1985-1994.

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