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Molecules 2013, 18(3), 3072-3085; doi:10.3390/molecules18033072
Article

Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta

1
,
2
,
1
,
2
 and
1,*
1 Drug Development Program, Biomedical Science Institute, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue 373, 21941-902, Rio de Janeiro, RJ, Brazil 2 Natural Products Research Nucleus, Health Science Center, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue 373, 21941-902, Rio de Janeiro, RJ, Brazil
* Author to whom correspondence should be addressed.
Received: 2 January 2013 / Revised: 27 February 2013 / Accepted: 1 March 2013 / Published: 7 March 2013
(This article belongs to the Section Natural Products)
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Abstract

The essential oil of Pectis brevipedunculata (EOPB), a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%), limonene (4.7%) and α-pinene (3.4%). Vasodilation induced by EOPB and isolated citral was investigated in pre-contracted vascular smooth muscle, using thoracic aorta from Wistar Kyoto (WKY) rats which was prepared for isometric tension recording. EOPB promoted intense relaxation of endothelium-intact and denuded aortic rings with the concentration to induce 50% of the maximal relaxation (IC50) of 0.044% ± 0.006% and 0.093% ± 0.015% (p < 0.05), respectively. The IC50 values for citral in endothelium-intact and denuded rings were 0.024% ± 0.004% and 0.021% ± 0.004%, respectively (p > 0.05). In endothelium-intact aorta, EOPB-induced vasorelaxation was significantly reduced by L-NAME, a nitric oxide synthase inhibitor. The vasodilator activity of citral was increased in the KCl-contracted aorta and citral attenuated the contracture elicited by Ca2+ in depolarized aorta. EOPB and citral elicited vasorelaxation on thoracic aorta by affecting the NO/cyclic GMP pathway and the calcium influx through voltage-dependent L-type Ca2+ channels, respectively.
Keywords: Pectis brevipedunculata; citral; vasodilator effect; L-type Ca2+ channel; NO/cyclic GMP pathway Pectis brevipedunculata; citral; vasodilator effect; L-type Ca2+ channel; NO/cyclic GMP pathway
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pereira, S.; Marques, A.; Sudo, R.T.; Kaplan, M.A.; Zapata-Sudo, G. Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta. Molecules 2013, 18, 3072-3085.

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