Next Article in Journal
Differences in the Phenolic Composition and Antioxidant Properties between Vitis coignetiae and Vitis vinifera Seeds Extracts
Next Article in Special Issue
Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides
Previous Article in Journal
Diosgenone Synthesis, Anti-Malarial Activity and QSAR of Analogues of This Natural Product
Previous Article in Special Issue
3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers
Article Menu

Export Article

Open AccessReview
Molecules 2013, 18(3), 3379-3409; doi:10.3390/molecules18033379

Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases

Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Received: 29 December 2012 / Revised: 25 February 2013 / Accepted: 7 March 2013 / Published: 14 March 2013
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)

Abstract

Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the design and synthesis of radiolabeled peptides for clinical applications are described.
Keywords: radionuclides; chelator; prosthetic groups; carrier molecules; peptides; medicinal application; radiopharmaceutical; diagnostic imaging; radiotherapeutics radionuclides; chelator; prosthetic groups; carrier molecules; peptides; medicinal application; radiopharmaceutical; diagnostic imaging; radiotherapeutics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jamous, M.; Haberkorn, U.; Mier, W. Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases. Molecules 2013, 18, 3379-3409.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top