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Molecules 2013, 18(4), 3689-3702; doi:10.3390/molecules18043689

Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells

1, 2, 1,* , 2,*  and 1
1 College of Medical, Dalian University, Dalian 116622, China 2 College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China
* Authors to whom correspondence should be addressed.
Received: 20 December 2012 / Revised: 10 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
(This article belongs to the Section Organic Synthesis)
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Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
Keywords: ginsenoside; synthesis; cytotoxicity; MGC80-3 ginsenoside; synthesis; cytotoxicity; MGC80-3
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, W.-F.; Chen, L.-R.; Gong, X.-J.; Li, Z.-N.; Li, K.-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules 2013, 18, 3689-3702.

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