Next Article in Journal
Comparing the Suitability of Autodock, Gold and Glide for the Docking and Predicting the Possible Targets of Ru(II)-Based Complexes as Anticancer Agents
Next Article in Special Issue
Modulation of Xenobiotic Receptors by Steroids
Previous Article in Journal
Synthesis of Structured Lipids by Lipase-Catalyzed Interesterification of Triacetin with Camellia Oil Methyl Esters and Preliminary Evaluation of their Plasma Lipid-Lowering Effect in Mice
Previous Article in Special Issue
The Use of Stable and Radioactive Sterol Tracers as a Tool to Investigate Cholesterol Degradation to Bile Acids in Humans in Vivo
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(4), 3745-3759; doi:10.3390/molecules18043745

In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release

Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014, Finland
Author to whom correspondence should be addressed.
Received: 25 February 2013 / Revised: 19 March 2013 / Accepted: 21 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Steroids)
View Full-Text   |   Download PDF [452 KB, uploaded 18 June 2014]   |  


In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macro- and microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with regard to their potential applications in drug delivery, particularly in a pH-controlled drug release.
Keywords: organogel; acid-responsive; cholesterol; in situ gelation; drug release organogel; acid-responsive; cholesterol; in situ gelation; drug release
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bunzen, H.; Kolehmainen, E. In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release. Molecules 2013, 18, 3745-3759.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top