Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives
AbstractA series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.
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Mabkhot, Y.N.; Kheder, N.A.; Farag, A.M. Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives. Molecules 2013, 18, 4669-4678.
Mabkhot YN, Kheder NA, Farag AM. Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives. Molecules. 2013; 18(4):4669-4678.Chicago/Turabian Style
Mabkhot, Yahia N.; Kheder, Nabila A.; Farag, Ahmad M. 2013. "Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives." Molecules 18, no. 4: 4669-4678.