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Molecules 2013, 18(4), 4739-4765; doi:10.3390/molecules18044739

Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids

School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa
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Received: 19 March 2013 / Revised: 10 April 2013 / Accepted: 19 April 2013 / Published: 22 April 2013
(This article belongs to the Special Issue Suzuki Reaction)

Abstract

The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids that are discussed are the chalcones, flavones, isoflavones, neoflavones, biflavones and derivatives of flavonoids obtained by C-C bond formation via the Suzuki-Miyaura reaction. View Full-Text
Keywords: Suzuki-Miyaura reaction; flavonoid; chalcone; flavone; isoflavone; neoflavone; 4-arylcoumarin; biflavone Suzuki-Miyaura reaction; flavonoid; chalcone; flavone; isoflavone; neoflavone; 4-arylcoumarin; biflavone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Selepe, M.A.; Van Heerden, F.R. Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids. Molecules 2013, 18, 4739-4765.

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