Next Article in Journal
Anionic Calixarene-Capped Silver Nanoparticles Show Species-Dependent Binding to Serum Albumins
Previous Article in Journal
Interactive Effect of Salicylic Acid on Some Physiological Features and Antioxidant Enzymes Activity in Ginger (Zingiber officinale Roscoe)
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(5), 5980-5992; doi:10.3390/molecules18055980

Synthesis of Micheliolide Derivatives and Their Activities against AML Progenitor Cells

1
College of Pharmacy, the State Key Laboratory of Elemento-Organic Chemistry, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China
2
College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
3
Accendatech Co., Ltd, Tianjin 300384, China
*
Authors to whom correspondence should be addressed.
Received: 27 April 2013 / Revised: 15 May 2013 / Accepted: 16 May 2013 / Published: 21 May 2013
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [268 KB, uploaded 18 June 2014]   |  

Abstract

Micheliolide (MCL) derivatives with etherification or esterification of the hydroxyl group at the C4 position were synthesized and evaluated for their activities against different acute myelogenous leukemia (AML) cell lines. These derivatives demonstrated comparable activities against AML cell lines HL-60 and doxorubicin resistant cell line HL-60/A. As to multi-drug resistant AML progenitor cells KG-1a, MCL and some of its derivatives maintained significant activities, and only 1.1–2.7 fold activity reductions were observed when compared with the activities against HL-60, while doxorubicin showed 20-fold activity reduction. Our study demonstrated that the C4 hydroxyl group of MCL might not only be a suitable position for structural modifications, but also be a starting point for the design of appropriate molecular probes to explore the specific targets in the progenitor cell line KG-1a. View Full-Text
Keywords: leukemia progenitor cell; micheliolide; KG-1a; deriviative; sythesis leukemia progenitor cell; micheliolide; KG-1a; deriviative; sythesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ma, W.-W.; Shi, Q.-Q.; Ding, Y.-H.; Long, J.; Zhang, Q.; Chen, Y. Synthesis of Micheliolide Derivatives and Their Activities against AML Progenitor Cells. Molecules 2013, 18, 5980-5992.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top