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Molecules 2013, 18(6), 6215-6229; doi:10.3390/molecules18066215

Comparing Conventional and Supercritical Extraction of (−)-Mammea A/BB and the Antioxidant Activity of Calophyllum brasiliense Extracts

1
Programa de Pós-Graduação em Engenharia Química, Universidade Estadual de Maringá (UEM), Av. Colombo, 5790, Bloco E-46, 87020-900 Maringá, Paraná, Brazil
2
Faculdade de Farmácia, Departamento de Produtos Naturais e Alimentos, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Bloco A, 2°andar, Ilha do Fundão, Cidade Universitária, 21941-902, RJ, Rio de Janeiro, Brazil
3
Programa de Pós-Graduação em Ciências Farmacêuticas, Av. Colombo, 5790, Bloco K-68, 87020-900 Maringá, Paraná, Brazil
4
Programa de Pós-Graduação em Engenharia Química, Universidade Estadual do Oeste do Paraná (UNIOESTE), Caixa postal 520, 85903-000,Toledo, Paraná, Brazil
*
Author to whom correspondence should be addressed.
Received: 5 March 2013 / Revised: 18 May 2013 / Accepted: 20 May 2013 / Published: 24 May 2013
(This article belongs to the Section Natural Products)
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Abstract

Calophyllum brasiliense is a rich source of bioactive coumarins, xanthones and biflavonoids. The aim of the study was to compare the phenol contents and the antioxidant activity of C. brasiliense extracts obtained by conventional and supercritical fluid extraction (SFE) methods, as well as the quantification of crude extracts and (−)-mammea A/BB yields. Dichloromethane and hexane were used as solvents for the conventional extractions and SFE was developed using supercritical CO2; the kinetic curves were modeled using a second-order empirical model. The dichloromethane extract presented the best total yield, although it showed the lowest content of (−)-mammea A/BB. The concentration of the coumarin was considerably higher in extracts obtained by the supercritical fluid method and a higher antioxidant activity was assigned to extracts obtained by this technique. Concerning the total phenolic contents, both the dichloro-methane and the supercritical extractions produced satisfactory amounts. The SFE method proved to be more promising than conventional methods.
Keywords: Calophyllum brasiliense; supercritical extraction; (−)-mammea A/BB; antioxidant activity; total phenols; mathematical modeling Calophyllum brasiliense; supercritical extraction; (−)-mammea A/BB; antioxidant activity; total phenols; mathematical modeling
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MDPI and ACS Style

Gonçalves, R.M.; Lemos, C.O.T.; Leal, I.C.R.; Nakamura, C.V.; Cortez, D.A.G.; da Silva, E.A.; Cabral, V.F.; Cardozo-Filho, L. Comparing Conventional and Supercritical Extraction of (−)-Mammea A/BB and the Antioxidant Activity of Calophyllum brasiliense Extracts. Molecules 2013, 18, 6215-6229.

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