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Molecules 2013, 18(8), 9253-9277; doi:10.3390/molecules18089253

Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins

Department of Chemistry, University of Wyoming, Laramie, WY 82071, USA
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Received: 6 June 2013 / Revised: 27 July 2013 / Accepted: 29 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue NMR of Proteins and Small Biomolecules)
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Abstract

Bleomycins are a family of glycopeptide antibiotics that have the ability to bind and degrade DNA when bound to key metal ions, which is believed to be responsible for their antitumor activity. Knowledge of the structures of metallo-bleomycins is vital to further characterize their mechanism of action. To this end, numerous structural studies on metallo-bleomycins have been conducted. NMR spectroscopy has had a key role in most of these studies, and has led to very important findings involving the coordination chemistry of metallo-bleomycins, and the details of many metallo-bleomycin-DNA spatial correlations for this important drug. This paper reviews the most important contributions of NMR to the bleomycin field.
Keywords: antibiotic; cancer; bleomycin; solution structures antibiotic; cancer; bleomycin; solution structures
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lehmann, T.; Topchiy, E. Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins. Molecules 2013, 18, 9253-9277.

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