Next Article in Journal
An Azabisphosphonate-Capped Poly(phosphorhydrazone) Dendrimer for the Treatment of Endotoxin-Induced Uveitis
Previous Article in Journal
Advances in Kinetic Isotope Effect Measurement Techniques for Enzyme Mechanism Study
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(8), 9293-9304; doi:10.3390/molecules18089293

Anti-Oxidant and Anti-Inflammatory Activities of Inonotus obliquus and Germinated Brown Rice Extracts

Department of Life Science, College of Biomedical and Health Science, Research Institute of Inflammatory Disease, Konkuk University, Chungju 380-701, Korea
*
Author to whom correspondence should be addressed.
Received: 13 June 2013 / Revised: 28 July 2013 / Accepted: 30 July 2013 / Published: 2 August 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [296 KB, uploaded 18 June 2014]   |  

Abstract

Inonotus obliquus (IO) is parasitic mushroom that grows on birch and other trees in Russia, Korea, Europe and United States. However, IO is not readily available for consumption due to its high cost and difficult growth. In this regard, IO was inoculated on germinated brown rice (GBR) in the present study and the antioxidant and anti-inflammatory activities of the IO grown on germinated brown rice (IOGBR) extracts were evaluated extensively and compared with those for IO and GBR. IOGBR showed highest antioxidant activities with scavenging total intracellular ROS and MDA levels as well as increasing the antioxidant enzymes activity in the H2O2-stimulated mice liver. It also exhibited best inflammatory activities by suppressing the proinflammatory mediators such as NO, PGE2, iNOS, COX-2, TNF-α, IL-1β, and IL-6 in an LPS-stimulated RAW 264.7 cell line. This study provides a comparative approach to find out an excellent natural source of antioxidants and anti-inflammatory agent as a dietary supplement. View Full-Text
Keywords: dietary supplement; ROS; antioxidant enzyme; pro-inflammatory cytokine dietary supplement; ROS; antioxidant enzyme; pro-inflammatory cytokine
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Debnath, T.; Park, S.R.; Kim, D.H.; Jo, J.E.; Lim, B.O. Anti-Oxidant and Anti-Inflammatory Activities of Inonotus obliquus and Germinated Brown Rice Extracts. Molecules 2013, 18, 9293-9304.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top