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Molecules 2013, 18(8), 9531-9549; doi:10.3390/molecules18089531

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

1,2,3, 4,*  and 3,*
1 Montreal Heart Institute, Research Center, 5000 Bélanger Est, Montréal, QC H1T 1C8, Canada 2 Institute of Biomedical Engineering, École Polytechnique de Montréal, Montreal, QC H3C 3A7, Canada 3 Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montréal, QC H3A 0B8 Canada 4 Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montreal, QC H3G 1Y6, Canada
* Authors to whom correspondence should be addressed.
Received: 1 July 2013 / Revised: 3 August 2013 / Accepted: 5 August 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Advances in Click Chemistry)
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The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of “click” chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.
Keywords: click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Avti, P.K.; Maysinger, D.; Kakkar, A. Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology. Molecules 2013, 18, 9531-9549.

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