Click Chemistry in Peptide-Based Drug Design
AbstractClick chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes in both chemical and biological fields. In this review, we discuss the application of click chemistry in peptide-based drug design. We highlight how triazoles formed by click reactions have been used for mimicking peptide and disulfide bonds, building secondary structural components of peptides, linking functional groups together, and bioconjugation. The progress made in this field opens the way for synthetic approaches to convert peptides with promising functional leads into structure-minimized and more stable forms. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Li, H.; Aneja, R.; Chaiken, I. Click Chemistry in Peptide-Based Drug Design. Molecules 2013, 18, 9797-9817.
Li H, Aneja R, Chaiken I. Click Chemistry in Peptide-Based Drug Design. Molecules. 2013; 18(8):9797-9817.Chicago/Turabian Style
Li, Huiyuan; Aneja, Rachna; Chaiken, Irwin. 2013. "Click Chemistry in Peptide-Based Drug Design." Molecules 18, no. 8: 9797-9817.