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Molecules 2013, 18(9), 10312-10319; doi:10.3390/molecules180910312

Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum

1,* , 1
1 Section of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway 2 Department of Traditional Medicine, Institut National de Recherche en Santé Publique, BP 1746, Bamako, Mali
* Authors to whom correspondence should be addressed.
Received: 3 July 2013 / Revised: 8 August 2013 / Accepted: 14 August 2013 / Published: 26 August 2013
(This article belongs to the Section Natural Products)
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Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides.
Keywords: Biophytum umbraculum; flavone-C-glycosides; DPPH; xanthine oxidase; 15-lipoxygenase Biophytum umbraculum; flavone-C-glycosides; DPPH; xanthine oxidase; 15-lipoxygenase
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pham, A.T.; Nguyen, C.; Malterud, K.E.; Diallo, D.; Wangensteen, H. Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum. Molecules 2013, 18, 10312-10319.

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