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Molecules 2013, 18(9), 10367-10377; doi:10.3390/molecules180910367

3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

1
Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400 Serdang, Malaysia
2
Bright Sparks Unit, University Malaya, 53500 Kuala Lumpur, Malaysia
3
Faculty of industrial Sciences & Technology, Universiti Malaysia Pahang, 26300 Lebuhraya Tun Razak, Kuantan Pahang, Malaysia
4
The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
5
Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Malaysia
*
Author to whom correspondence should be addressed.
Received: 8 June 2013 / Revised: 12 August 2013 / Accepted: 15 August 2013 / Published: 27 August 2013
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Abstract

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line. View Full-Text
Keywords: anthraquinone; BHAQ; cytotoxic; MDA-MB231; MCF-7; migration anthraquinone; BHAQ; cytotoxic; MDA-MB231; MCF-7; migration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Abu, N.; Akhtar, M.N.; Ho, W.Y.; Yeap, S.K.; Alitheen, N.B. 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231. Molecules 2013, 18, 10367-10377.

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