Next Article in Journal
Impact of Organic and Inorganic Fertilizers Application on the Phytochemical and Antioxidant Activity of Kacip Fatimah (Labisia pumila Benth)
Next Article in Special Issue
Molecular Docking and Fluorescence Characterization of Benzothieno[3,2-d]pyrimidin-4-one Sulphonamide Thio-Derivatives, a Novel Class of Selective Cyclooxygenase-2 Inhibitors
Previous Article in Journal
Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
Previous Article in Special Issue
Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells
Article Menu

Export Article

Open AccessReview
Molecules 2013, 18(9), 10953-10972; doi:10.3390/molecules180910953

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Laboratory of Cellular Communication, Oswaldo Cruz Foundation, AV. Brazil, 4365, Rio de Janeiro, Brazil
Laboratory of Immnopharmacology, Oswaldo Cruz Foundation, AV. Brazil 4365, Rio de Janeiro, Brazil
Author to whom correspondence should be addressed.
Received: 17 June 2013 / Revised: 26 August 2013 / Accepted: 27 August 2013 / Published: 5 September 2013
(This article belongs to the Special Issue Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry)
View Full-Text   |   Download PDF [218 KB, uploaded 18 June 2014]


The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms. Taken together, these results indicate that P2X7R is a promising pharmacological target, and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines. In this review, we discuss aspects of P2X7R pharmacology and the participation of this protein in inflammation and pain and provide an overview of some promising compounds that have been tested as antagonists of P2X7R, with clinical applicability.
Keywords: P2X7R; inflammatory response; antagonists and pharmacological target P2X7R; inflammatory response; antagonists and pharmacological target
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Alves, L.A.; Bezerra, R.J.S.; Faria, R.X.; Ferreira, L.G.B.; da Silva Frutuoso, V. Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain. Molecules 2013, 18, 10953-10972.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top