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Molecules 2013, 18(9), 11144-11152; doi:10.3390/molecules180911144
Article

An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

1,2,†, 2,†, 2, 2, 2, 2,*  and 1,2,*
1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China 2 Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 23 August 2013 / Revised: 3 September 2013 / Accepted: 4 September 2013 / Published: 11 September 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Keywords: anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, X.-Y.; Xia, G.-Q.; Wang, X.-K.; Zheng, Z.-B.; Zhao, D.-M.; Zhao, G.-M.; Li, S. An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs. Molecules 2013, 18, 11144-11152.

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