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Molecules 2014, 19(8), 12328-12335; doi:10.3390/molecules190812328

PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

1 University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA 2 Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East, G-3630, Seattle, WA 98109-1023, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 July 2014 / Revised: 11 August 2014 / Accepted: 11 August 2014 / Published: 15 August 2014
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.
Keywords: PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Petek, B.J.; Jones, R.L. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules 2014, 19, 12328-12335.

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