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Molecules 2017, 22(12), 2168; doi:10.3390/molecules22122168

Multi-Component One-Pot Reaction of Aromatic Carbonyl Compounds, Tosylhydrazide, and Arylboronic Acids

Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China
Authors to whom correspondence should be addressed.
Received: 26 November 2017 / Revised: 4 December 2017 / Accepted: 6 December 2017 / Published: 7 December 2017
(This article belongs to the Special Issue Base Metal Catalysis and Green Synthesis)
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In this paper, we developed a new method using 4-bromoacetophenone as the starting material, with tosylhydrazide and two arylboronic acids using Barluenga and Suzuki couplings in a four-component one-pot reaction to afford the target product 4-benzyl-1,1′-biphenyls. This system that we have developed enables the use of easily accessible starting materials and can be employed on a wide variety of substrates with good functional group tolerance. In particular, this protocol can be applied to the synthesis of 4-(1-([1,1′-biphenyl]-4-yl)ethyl)pyridine derivatives, a class of potential analogs of CPY17 inhibitors of prostate cancer. View Full-Text
Keywords: one-pot reaction; tosylhydrazide; arylboronic acid; 4-benzyl-1,1′-biphenyl derivatives one-pot reaction; tosylhydrazide; arylboronic acid; 4-benzyl-1,1′-biphenyl derivatives

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gu, N.; Wei, Y.; Liu, P.; Liu, Y.; Dai, B. Multi-Component One-Pot Reaction of Aromatic Carbonyl Compounds, Tosylhydrazide, and Arylboronic Acids. Molecules 2017, 22, 2168.

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