Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes
AbstractSeparation of the enantiomers of new chiral alkynes in strategic syntheses and bioorthogonal studies is always problematic. The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such substrates, since the differentiation of the alkyne segment with the other alkane/alkene segment is not significant in the stationary phase, and the alkyne group is not a good UV chromophore. Usually, a pre-column derivatization reaction with a tedious workup procedure is needed. Making use of easily-prepared stable alkyne-cobalt-complexes, we developed a simple and general method by analyzing the in situ generated cobalt-complex of chiral alkynes using chiral column HPLC. This new method is especially suitable for the alkynes without chromophores and other derivable groups. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2821 KB)
Share & Cite This Article
Liu, Q.; Wang, J.; Li, J.; Wang, X.; Lu, S.; Li, X.; Gong, Y.; Xu, S. Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes. Molecules 2017, 22, 466.
Liu Q, Wang J, Li J, Wang X, Lu S, Li X, Gong Y, Xu S. Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes. Molecules. 2017; 22(3):466.Chicago/Turabian Style
Liu, Qiaoyun; Wang, Jing; Li, Junfei; Wang, Xiaolei; Lu, Shichao; Li, Xuan; Gong, Yaling; Xu, Shu. 2017. "Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes." Molecules 22, no. 3: 466.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.