Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives
AbstractA comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition. View Full-Text
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Rioton, S.; Pardo, D.G.; Cossy, J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules 2017, 22, 483.
Rioton S, Pardo DG, Cossy J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules. 2017; 22(3):483.Chicago/Turabian Style
Rioton, Sarah; Pardo, Domingo G.; Cossy, Janine. 2017. "Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives." Molecules 22, no. 3: 483.
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