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Molecules 2017, 22(4), 653; doi:10.3390/molecules22040653

Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
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Academic Editor: Diego Muñoz-Torrero
Received: 10 March 2017 / Revised: 12 April 2017 / Accepted: 14 April 2017 / Published: 20 April 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [8629 KB, uploaded 20 April 2017]   |  

Abstract

Gamma-Aminobutyric acid (GABA) could regulate physiological functions in the gastrointestinal tract. The present study aimed to investigate the effect of GABA on colon health in mice. The female Kunming mice were given GABA at doses of 5, 10, 20 and 40 mg/kg/d for 14 days. Afterwards, the short-chain fatty acids (SCFAs) concentrations, pH values, colon index, colon length and weight of colonic and cecal contents were determined to evaluate the effects of GABA on colon health. The results showed that intake of GABA could increase the concentrations of acetate, propionate, butyrate and total SCFAs in colonic and cecal contents, as well as the weight of colonic and cecal contents. The colon index and length of the 40 mg/kg/d GABA-treated group were significantly higher than those of the control group (p < 0.05). In addition, decrease of pH values in colonic and cecal contents was also observed. These results suggest that GABA may improve colon health. View Full-Text
Keywords: gamma-aminobutyric acid; colon; SCFAs; pH values gamma-aminobutyric acid; colon; SCFAs; pH values
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MDPI and ACS Style

Xie, M.; Chen, H.-H.; Nie, S.-P.; Yin, J.-Y.; Xie, M.-Y. Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon. Molecules 2017, 22, 653.

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