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Molecules 2017, 22(4), 654; doi:10.3390/molecules22040654

Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Couple Preparations Improved by Chito-Oligosaccharide via Integral Pharmacokinetics

1
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China
3
Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China
4
Faculty of Health Sciences, University of Macau, Macau SAR, China
5
Department of Pharmacy, Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China
6
Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Paediatrics, Nanjing University of Chinese Medicine, Nanjing 210021, China
*
Author to whom correspondence should be addressed.
Academic Editors: Derek J. McPhee and Thomas J. Schmidt
Received: 22 February 2017 / Revised: 8 April 2017 / Accepted: 11 April 2017 / Published: 20 April 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [10429 KB, uploaded 24 April 2017]   |  

Abstract

In the present study, the rationality for the antiviral effect (H1N1 virus) of Flos Lonicerae Japonicae (FLJ, named JinYinHua)-Fructus forsythiae (FF, named LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that the improvement of antiviral activity for four preparations attributed to the enhancement of bioavailability for the FLJ-FF herb couple in vivo, and that caffeic acid derivatives are the most important type of components for antiviral activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC50), not area under concentration (AUC) was considered as the weighting factor for integrating the pharmacokinetics of caffeic acid derivatives. It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. The results indicated that the antiviral activity in four preparations improved by COS was mainly attributed to the integral absorption enhancement of caffeic acid derivatives. View Full-Text
Keywords: Flos Lonicerae Japonicae-Fructus forsythiae herb couple; integral pharmacokinetics; multiple caffeic acid derivatives; chito-oligosaccharide; tight junction; anti-viral activity Flos Lonicerae Japonicae-Fructus forsythiae herb couple; integral pharmacokinetics; multiple caffeic acid derivatives; chito-oligosaccharide; tight junction; anti-viral activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, W.; Yin, A.; Shan, J.; Wang, S.; Cai, B.; Di, L. Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Couple Preparations Improved by Chito-Oligosaccharide via Integral Pharmacokinetics. Molecules 2017, 22, 654.

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