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Molecules 2017, 22(4), 660; doi:10.3390/molecules22040660

Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos

1
School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, Guangdong, China
2
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
3
School of Nursing, Guangdong Pharmaceutical University, Guangzhou 510310, Guangdong, China
4
Chn-Alternative Biotech Co. Ltd., Guangzhou 510432, Guangdong, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Julio A. Seijas Vázquez
Received: 25 February 2017 / Revised: 9 April 2017 / Accepted: 15 April 2017 / Published: 21 April 2017
(This article belongs to the Special Issue ECSOC-20)
View Full-Text   |   Download PDF [4159 KB, uploaded 21 April 2017]   |  

Abstract

Tanshinone IIA (Tan-IIA) is derived from the dried roots of Salvia miltiorrhiza Bunge, a traditional Chinese medicine. Although Salvia miltiorrhiza has been applied for many years, the toxicity of the mono-constituent of Salvia miltiorrhiza, tanshinone IIA, is still understudied. This study evaluated the cardiotoxicity and developmental malformations of Tan-IIA by using zebrafish normal embryos and dechorionated embryos. After treatment with Tan-IIA in different concentrations for four-day periods, obvious pericardial edema, spinal curvature, and even missing tails were observed in zebrafish embryos. The LC50 values in the dechorionated embryo group at 72 h post-fertilization (hpf) and 96 hpf were 18.5 μM and 12.8 μM, respectively, and the teratogenicity was manifested at a concentration of about 1 µM. The main endpoints of teratogenicity were scoliosis, malformation of tail, and pericardium edema. Our findings displayed the potential cardiotoxicity and severe impact on the abnormal development of Tan-IIA in zebrafish embryo at high concentrations, which may help avoid the risk of its clinical application. View Full-Text
Keywords: zebrafish; tanshinone IIA; developmental toxicity zebrafish; tanshinone IIA; developmental toxicity
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Wang, T.; Wang, C.; Wu, Q.; Zheng, K.; Chen, J.; Lan, Y.; Qin, Y.; Mei, W.; Wang, B. Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos. Molecules 2017, 22, 660.

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