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Molecules, Volume 3, Issue 1 (January 1998), Pages 1-30, Articles M43-M45

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Research

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Open AccessArticle Synthesis and Intramolecular [4+2] Cycloaddition Reactions of 4-Pyridazinecarbonitriles with Alkyne Side Chains
Molecules 1998, 3(1), 10-15; doi:10.3390/30100010
Received: 15 October 1997 / Accepted: 19 November 1997 / Published: 25 January 1998
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Abstract
The preparation of a series of new 3-(alkynyl-X)-substituted 4-pyridazinecarbonitriles 2-5 (X = O, NH) is described. The compounds are shown to undergo thermally induced intramolecular Diels-Alder reactions with inverse electron demand, affording the fused benzonitriles 6-8. Incorporation of a 1,2-phenylene unit into the
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The preparation of a series of new 3-(alkynyl-X)-substituted 4-pyridazinecarbonitriles 2-5 (X = O, NH) is described. The compounds are shown to undergo thermally induced intramolecular Diels-Alder reactions with inverse electron demand, affording the fused benzonitriles 6-8. Incorporation of a 1,2-phenylene unit into the side chain, as in the case of compounds 10 and 13, results in a more favorable conformation of the dienophilic substructure and thus to a pronounced acceleration of the [4+2] cycloaddition reaction. Full article
Open AccessArticle Synthesis and Biological Evaluation of 14 -Methoxy Digitalis Derivatives
Molecules 1998, 3(1), 20-25; doi:10.3390/30100020
Received: 11 November 1997 / Accepted: 15 January 1998 / Published: 25 January 1998
PDF Full-text (45 KB)
Abstract
The synthesis and biological evaluation of 14β-methoxy derivatives of digitoxigenin and of other digitalis-like compounds are reported. These compounds have a 14β-oxygen, which can be a hydrogen bonding acceptor, as is the case of 14β,15β-epoxide derivatives, but not a hydrogen bonding donor as
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The synthesis and biological evaluation of 14β-methoxy derivatives of digitoxigenin and of other digitalis-like compounds are reported. These compounds have a 14β-oxygen, which can be a hydrogen bonding acceptor, as is the case of 14β,15β-epoxide derivatives, but not a hydrogen bonding donor as is the case of 14β-hydroxy derivatives. All the new 14β-methoxy derivatives show a considerable reduced binding affinity on Na+,K+-ATPase when compared with the 14β-hydroxy analogues and also with the 14β,15β-epoxy derivatives. These results could mean that the digitalis receptor does not permit the presence of a bulky substituent in the 14β region, even of relatively small volume like the methyl group Full article
Open AccessCommunication Nucleophilic Additions of 2-Furyllithium to Carbonyl Derivatives of L-Serine. Formal Synthesis of (2R,3R)-β-Hydroxy Aspartic Acid
Molecules 1998, 3(1), 26-30; doi:10.3390/30100026
Received: 1 October 1997 / Accepted: 15 January 1998 / Published: 25 January 1998
Cited by 1 | PDF Full-text (28 KB)
Abstract
The nucleophilic addition of 2-furyllithium to esters derived from L-serine is described. The obtained furyl ketone 5 is stereoselectively reduced (ds≥95%) with sodium borohydride to afford the corresponding syn aminoalcohol 12 in enantiomerically pure form. Compound 12 was further converted into valuable α-hydroxy-β-amino
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The nucleophilic addition of 2-furyllithium to esters derived from L-serine is described. The obtained furyl ketone 5 is stereoselectively reduced (ds≥95%) with sodium borohydride to afford the corresponding syn aminoalcohol 12 in enantiomerically pure form. Compound 12 was further converted into valuable α-hydroxy-β-amino acids by means of the furan-to-acid equivalence. Full article

Review

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Open AccessReview 4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators
Molecules 1998, 3(1), 1-9; doi:10.3390/30100001
Received: 29 October 1997 / Accepted: 8 December 1997 / Published: 25 January 1998
Cited by 78 | PDF Full-text (272 KB)
Abstract Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized. Full article
Open AccessReview Review of the Molecule of the Month Website in 1997
Molecules 1998, 3(1), 16-19; doi:10.3390/30100016
Received: 12 December 1997 / Accepted: 14 January 1998 / Published: 25 January 1999
Cited by 1 | PDF Full-text (136 KB)
Abstract This review describes the history of the "Molecule of the Month" Website, along with a short summary of some of the molecules which featured during 1997. Full article

Other

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Open AccessShort Note 3-Bis(5-methylfur-2-yl)methyl-2,4-pentanedion
Molecules 1998, 3(1), M43; doi:10.3390/M43
Received: 22 December 1997 / Published: 25 January 1998
PDF Full-text (96 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2-Cyanophenylbis(5-methylfur-2-yl)methane
Molecules 1998, 3(1), M44; doi:10.3390/M44
Received: 22 December 1997 / Published: 25 January 1998
PDF Full-text (76 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note a,a,a',a'- Tetra(5-methylfur-2-yl)-p-xylene
Molecules 1998, 3(1), M45; doi:10.3390/M45
Received: 22 December 1997 / Published: 25 January 1998
PDF Full-text (85 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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