Research

Jump to: Review

117 KiB

Open AccessShort Note

Cycloartan-2b-2-methyl ButanoateIsolated from Genus Espeletia (Asteraceae)

by Tellez Nohemi, Torrenegra Ruben, Pedroyo Julio and Gray Alexander

Molecules 1998, 3(3), M49; https://doi.org/10.3390/M49 - 04 Mar 1998

Cited by 2 | Viewed by 3011

We describe the isolation and characterization of a new cycloartane-type triterpenes, cycloartan- 2b-2-methyl butanoate.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

Methyl 2,3-O-Isopropylidene-a-D-mannofuranoside 5,6-Carbonate

by Bohumil Steiner, Jan Gajdos and Miroslav Koos

Molecules 1998, 3(3), M50; https://doi.org/10.3390/M50 - 04 Mar 1998

Viewed by 2933

Abstract

Sugar carbonates can be prepared by the condensation of the cis-glycol system of the carbohydrate with phosgene or with a chloroformic ester [1,2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

119 KiB

Open AccessShort Note

Ethyl (E)-3-methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M51; https://doi.org/10.3390/M51 - 06 Mar 1998

Cited by 1 | Viewed by 3900

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

115 KiB

Open AccessShort Note

Ethyl (Z)-3-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M52; https://doi.org/10.3390/M52 - 06 Mar 1998

Viewed by 3725

Abstract

The synthetic procedure [1] has been presented elsewhere. Ethyl (Z)-3-methyl-5-phenyl-2-pentenoate was obtained (2.23 g, 23%) as a colourless oil.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

105 KiB

Open AccessShort Note

(E)-3-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M53; https://doi.org/10.3390/M53 - 06 Mar 1998

Viewed by 3809

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

102 KiB

Open AccessShort Note

(Z)-3-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M54; https://doi.org/10.3390/M54 - 06 Mar 1998

Viewed by 4029

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

103 KiB

Open AccessShort Note

2(S,R),3(R,S)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M55; https://doi.org/10.3390/M55 - 06 Mar 1998

Cited by 2 | Viewed by 4171

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

103 KiB

Open AccessShort Note

2(R,S),3(S,R)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M56; https://doi.org/10.3390/M56 - 06 Mar 1998

Cited by 1 | Viewed by 3921

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

102 KiB

Open AccessShort Note

(Z)-1-Bromo-2-methyl-4-phenyl-1-butene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M57; https://doi.org/10.3390/M57 - 06 Mar 1998

Viewed by 3795

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

► Show Figures

Figure 1

104 KiB

Open AccessShort Note

(E)-1-Bromo-2-methyl-4-phenyl-1-butene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M58; https://doi.org/10.3390/M58 - 06 Mar 1998

Viewed by 4083

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

97 KiB

Open AccessShort Note

Ethyl 3-Hydroxy-3-methyl-5-phenylpentanoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M59; https://doi.org/10.3390/M59 - 06 Mar 1998

Cited by 1 | Viewed by 3740

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

98 KiB

Open AccessShort Note

Ethyl 3-Acetoxy-3-methyl-5-phenylpentanoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M60; https://doi.org/10.3390/M60 - 06 Mar 1998

Viewed by 3669

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

97 KiB

Open AccessShort Note

3-Hydroxy-3-methyl-5-phenylpentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M61; https://doi.org/10.3390/M61 - 06 Mar 1998

Viewed by 3751

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

116 KiB

Open AccessShort Note

Ethyl (E)-2-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M62; https://doi.org/10.3390/M62 - 06 Mar 1998

Viewed by 3884

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

112 KiB

Open AccessShort Note

Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M63; https://doi.org/10.3390/M63 - 06 Mar 1998

Viewed by 3729

Abstract

The synthetic procedure [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

104 KiB

Open AccessShort Note

(E)-2-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M64; https://doi.org/10.3390/M64 - 06 Mar 1998

Viewed by 3792

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

96 KiB

Open AccessShort Note

2,3-Dibromo-2-methyl-5-phenylpentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M65; https://doi.org/10.3390/M65 - 06 Mar 1998

Viewed by 3892

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

103 KiB

Open AccessShort Note

(Z)-2-Bromo-5-phenyl-2-pentene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M66; https://doi.org/10.3390/M66 - 06 Mar 1998

Viewed by 4193

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

102 KiB

Open AccessShort Note

Tributyl-[(Z)-5-phenyl-2-penten-2-yl]stannane

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M67; https://doi.org/10.3390/M67 - 06 Mar 1998

Cited by 3 | Viewed by 4048

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

99 KiB

Open AccessShort Note

[(Z)-5-Phenyl-2-penten-2-yl]mercury Bromide

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M68; https://doi.org/10.3390/M68 - 06 Mar 1998

Cited by 1 | Viewed by 3706

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

101 KiB

Open AccessShort Note

[(Z)-5-Phenyl-2-penten-2-yl]mercury Acetate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M69; https://doi.org/10.3390/M69 - 06 Mar 1998

Cited by 1 | Viewed by 3829

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

103 KiB

Open AccessShort Note

bis-[(Z)-5-Phenyl-2-penten-2-yl]mercury

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M70; https://doi.org/10.3390/M70 - 06 Mar 1998

Cited by 1 | Viewed by 3823

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

119 KiB

Open AccessShort Note

Ethyl (E)-3-(2-Methoxyphenyl)-2-butenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M71; https://doi.org/10.3390/M71 - 06 Mar 1998

Viewed by 3883

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

116 KiB

Open AccessShort Note

Ethyl (Z)-3-(2-Methoxyphenyl)-2-butenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M72; https://doi.org/10.3390/M72 - 06 Mar 1998

Cited by 1 | Viewed by 3850

Abstract

The synthetic procedure [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

106 KiB

Open AccessShort Note

(E)-3-(2-Methoxyphenyl)-2-butenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M73; https://doi.org/10.3390/M73 - 06 Mar 1998

Viewed by 3879

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

46 KiB

Open AccessArticle

Efficient Polymer-Supported Sharpless Alkene Epoxidation Catalyst

by Jaana K. Karjalainen, Osmo E.O. Hormi and David C. Sherrington

Molecules 1998, 3(3), 51-59; https://doi.org/10.3390/30300051 - 17 Feb 1998

Cited by 32 | Viewed by 9978

Abstract

Homogeneous linear poly(tartrate ester) ligands provide high chemical yields and enantiomeric excesses in the epoxidation of trans-hex-2-en-1-ol using Ti(OPrⁱ)₄-tert-butyl hydroperoxide. Branched poly(tartrate ester) can be use as heterogeneous ligands in the epoxidation of trans-hex-2-en-1-ol using [...] Read more.

Homogeneous linear poly(tartrate ester) ligands provide high chemical yields and enantiomeric excesses in the epoxidation of trans-hex-2-en-1-ol using Ti(OPrⁱ)₄-tert-butyl hydroperoxide. Branched poly(tartrate ester) can be use as heterogeneous ligands in the epoxidation of trans-hex-2-en-1-ol using Ti(OPrⁱ)₄-tert-butyl hydroperoxide. Removal and recovery of the polymer catalyst is a simple filtration at the end of reactions. Full article

► Show Figures

Scheme 1

22 KiB

Open AccessArticle

Intramolecular Cycloaddition of Imines of Cysteine Derivatives

by Ana M. T. D. P. V. Cabral, António M. D'A Rocha Gonsalves and Teresa M. V. D. Pinho e Melo

Molecules 1998, 3(3), 60-63; https://doi.org/10.3390/30300060 - 18 Feb 1998

Cited by 3 | Viewed by 7194

Abstract

Azomethine ylides were generated from Schiffs bases of S-allylcysteine methyl ester and their intramolecular 1,3-dipolar cycloadditions were studied. These reactions led to the synthesis of thieno[3,4-b]pyrrole derivatives in good yield. Full article

► Show Figures

Scheme 1

52 KiB

Open AccessArticle

An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds

by D. Craig and M. L. Marin

Molecules 1998, 3(3), 64-70; https://doi.org/10.3390/30300064 - 20 Feb 1998

Cited by 2 | Viewed by 7995

Abstract

A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using an [...] Read more.

A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using an intramolecular Diels-Alder reaction have been successful. Full article

► Show Figures

Figure 1

50 KiB

Open AccessArticle

Synthesis of Novel Fused Heterocycles Based on Pyrano[2,3-c]pyrazole

by M. E. A. Zaki

Molecules 1998, 3(3), 71-79; https://doi.org/10.3390/30300071 - 23 Feb 1998

Cited by 29 | Viewed by 6732

Abstract

3-Substituted 1,2,4-triazole derivatives (5, 9, 13, 16b, 19), pyrimidinium salts (21), triazines (24), and aryl methylene hydrazono pyrazolopyrano-pyrimidine (27a,b) which are rearranged in basic medium to 30a,b, were afforded via the reaction of 6-amino 1,4,5,6-tetrahydro-5-imino-3-methyl-1-phenyl-4 (pchlorophenyl) pyrazolo [4', 3' : 5,6]-pyrano [2,3-d] pyrimidine [...] Read more.

3-Substituted 1,2,4-triazole derivatives (5, 9, 13, 16b, 19), pyrimidinium salts (21), triazines (24), and aryl methylene hydrazono pyrazolopyrano-pyrimidine (27a,b) which are rearranged in basic medium to 30a,b, were afforded via the reaction of 6-amino 1,4,5,6-tetrahydro-5-imino-3-methyl-1-phenyl-4 (pchlorophenyl) pyrazolo [4', 3' : 5,6]-pyrano [2,3-d] pyrimidine (3) with different reagents. Full article

► Show Figures

Scheme 1

43 KiB

Open AccessArticle

Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition

by Tuvia Sheradsky and Elliad R. Silcoff

Molecules 1998, 3(3), 80-87; https://doi.org/10.3390/30300080 - 24 Feb 1998

Cited by 7 | Viewed by 7159

Abstract

The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso derivative of N-sorbyl-L-proline (5). L-Proline served as a temporary tether which directed both the stereochemistry and the regiochemistry [...] Read more.

The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso derivative of N-sorbyl-L-proline (5). L-Proline served as a temporary tether which directed both the stereochemistry and the regiochemistry of the cycloaddition. Full article

► Show Figures

Figure 1

55 KiB

Open AccessArticle

Application of Microwave in Organic Synthesis. Dry Synthesis of 2-Arylmethylene-3(2)-naphthofuranones

by Didier Villemin, Benoit Martin and Nathalie Bar

Molecules 1998, 3(3), 88-93; https://doi.org/10.3390/30300088 - 05 Mar 1998

Cited by 25 | Viewed by 8400

Abstract

3(2)-Naphthofuranone (1) was condensed in the presence of Al₂O₃-KF with aromatic aldehydes (4) to give arylidenenaphthofuranones (5a-f) without solvent under focused microwave irradiation. Full article

► Show Figures

Figure 1

41 KiB

Open AccessArticle

A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones

by Anatoly D. Shutalev, Ekaterina A. Kishko, Natalie V. Sivova and Aleksei Yu. Kuznetsov

Molecules 1998, 3(3), 100-106; https://doi.org/10.3390/30300100 - 09 Mar 1998

Cited by 121 | Viewed by 8048

Abstract

An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. Full article

► Show Figures

Scheme 1

466 KiB

Open AccessArticle

Enantiodivergent Synthesis of (R)- and (S)-Rolipram

by Joachim Demnitz, Luigi LaVecchia, Edmond Bacher, Thomas H. Keller, Thomas Müller, Friedrich Schürch, Hans-Peter Weber and Esteban Pombo-Villar

Molecules 1998, 3(3), 107-119; https://doi.org/10.3390/30300107 - 10 Mar 1998

Cited by 38 | Viewed by 10576

Abstract

Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation [...] Read more.

Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation gave (R)-(-)-1 and (S)-(+)-1, respectively. CD spectra of both enantiomers of rolipram are reported and discussed. Both enantiomers of rolipram presented the same potency of inhibitory activity against recombinant cyclic-AMP-selective phosphodiesterase (PDE4) subtypes. Full article

► Show Figures

Figure 1

68 KiB

Open AccessArticle

Evaluation of Effect of Microwave Irradiation on Syntheses and Reactions of Some New 3-Acyl-methylchromones

by Margita Lacova, Hafez M. El-Shaaer, Dusan Loos, Maria Matulova, Jarmila Chovancova and Mikulas Furdik

Molecules 1998, 3(3), 120-131; https://doi.org/10.3390/30300120 - 10 Mar 1998

Cited by 16 | Viewed by 7377

Abstract

The 3-Acyl-2-R-methylchromones (R = H, ArO, C₆H₄(CO)₂N) were prepared in good yields by different methods from 2-hydroxyaroylacetone derivatives. Some subsequent reactions of these compounds with hydroxylamine and 3-formylchromones are described. The effect of microwave irradation on some condensation reactions was studied. Full article

► Show Figures

Scheme 1

Review

Jump to: Research

414 KiB

Open AccessReview

Elemental and Molecular Heritage: An Internet-based Display

by Henry S. Rzepa

Molecules 1998, 3(3), 94-99; https://doi.org/10.3390/30300094 - 09 Mar 1998

Cited by 5 | Viewed by 8661

Abstract

The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are [...] Read more.

The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are shown, together with a recently discovered heterocyclic systems scorpionine, which like mauveine is made by a deceptively simple chemical synthesis. Full article

► Show Figures

Figure 1

Journal Menu

Journal Browser

Molecules, Volume 3, Issue 3 (March 1998) – 35 articles , Pages 51-131, Articles M49-M73

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI