Novel Coumarin Derivatives with Expected Biological Activity
Received: 13 August 1999 / Accepted: 20 October 1999 / Published: 16 February 2000
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A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro
on Ehrlich ascites carcinoma in the preliminary testing.