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Abstract

Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs

1
Cátedra de Química Orgánica, Facultad de Química, Universidad de la República. General Flores 2124, Montevideo, Uruguay
2
Departamento de Fisicoquímica Biológica, Facultad de Ciencias, Universidad de la República. General Flores 2124, Montevideo, Uruguay
3
Departamento de Bioquímica, Facultad de Medicina, Universidad de la República. General Flores 2124, Montevideo, Uruguay
Molecules 2000, 5(3), 497-498; https://doi.org/10.3390/50300497
Published: 22 March 2000

Abstract

:
Following our work in the synthesis of compounds with antichagasic activity, we describe new potential products in which the same “leader” compound was modulated.

Introduction

We have previously reported the synthesis and biological activity against Trypanosoma cruzi epimastigote forms in vitro and in vivo, of a series of semicarbazone derivatives of 5-nitrofurfural (“leader” compounds) [1,2].

Experimental

The synthesis of the new compounds is shown in the following scheme: Molecules 05 00497 i001
This compounds (I-IX), treated with Lawesson’ reagent, produced the thiocarbonyl compounds.

Results and Discussion

The new compounds were identified by 1H-NMR, 13C-NMR, IR, MS and were tested in vitro against epimastigote forms of Trypanosoma cruzi.

Acknowledgements 

The authors thank PEDECIBA Química and RELAQ (Red Latinoamericana de Ciencia Química).

References and Notes

  1. Cerecetto, H.; Di Maio, R.; Ibarruri, G.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C.; Paulino, M. Synthesis and anty-trypanosomal activity of novel 5-Nitro-2-furaldehyde and 5-Nitrotiophene-2-carboxaldehyde semicarbazones derivatives. Il farmaco 1998, 53, 89–94. [Google Scholar] [CrossRef]
  2. Cerecetto, H.; Di Maio, R.; González, M.; Risso, M.; Sagrera, G.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C.; Basombrío, M.A.; Stoppani, A.O.M.; Paulino, M.; Olea-Azar, C. Synthesis and anty-trypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-Nitrotiophene-2-carboxaldehyde semicarbazones. Eur. J. Med. Chem. (in press).

Share and Cite

MDPI and ACS Style

Cerecetto, H.; Di Maio, R.; Seoane, G.; Denicola, A.; Peluffo, G.; Quijano, C. Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs. Molecules 2000, 5, 497-498. https://doi.org/10.3390/50300497

AMA Style

Cerecetto H, Di Maio R, Seoane G, Denicola A, Peluffo G, Quijano C. Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs. Molecules. 2000; 5(3):497-498. https://doi.org/10.3390/50300497

Chicago/Turabian Style

Cerecetto, H., R. Di Maio, G. Seoane, A. Denicola, G. Peluffo, and C. Quijano. 2000. "Synthetic Modifications of Lead Compounds as Antitrypanosomal Drugs" Molecules 5, no. 3: 497-498. https://doi.org/10.3390/50300497

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