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Article

New Conjugated Systems Derived from Piperazine-2,5-dione

Chemistry Department, Faculty of Science, King Abdul-Aziz University, Jeddah 21413, P.O. Box 9028, Saudi Arabia
Molecules 2000, 5(3), 629-636; https://doi.org/10.3390/50300629
Submission received: 8 March 1999 / Revised: 25 November 1999 / Accepted: 30 December 1999 / Published: 10 March 2000

Abstract

:
The preparation of monoarylidene and both symmetrical and unsymmetrical bis- arylidene derivatives of piperazine-2,5-dione is described. The use of 1,4-diacetyl- piperazine-2,5-dione make it possible to prepare unsymmetrical bisarylidenes. The intro- duction of a dicyanomethylene moiety into the para position of one of the arylidene groups gave a remarkable deepening in the colour of the resulting compounds 11 and 16.

Introduction

The chemistry of piperazine-2,5-dione 1 is of great interest since many natural products contain this ring system [1,2,3]. Derivatives of 1 are useful in peptide synthesis [4], in the synthesis of pyrazines [5,6], and in Diels-Alder reactions as a 4π component [7]. Recent studies showed that 3-salicylidene- piperazine-2,5-dione 3 was supposed to be the most promising precursor for the synthesis of spiro[benzofuran-2(3H)-2’-piperzine]-3’,6’-dione as a main skeleton of aspirochlorine [8,9].
The structural similarity of derivative 3 to the chromophore of indigo 4, led us to assume that if the arylidene(piperazine-2,5-dione) system could be obtained with donor–acceptor substituents, then me- rostabilization of the excited state [10] should occur to give deeply coloured compounds that might be novel dyestuffs. This paper deals with the synthesis of mono- and bisarylidene derivatives possessing such donor and acceptor substituents.
Molecules 05 00629 i001

Results and Discussion

Piperazine-2,5-dione 1 was prepared by self condensation of glycine according to the literature [4]. 1,4-Diacetylpiperazine-2,5-dione 2 was prepared by treating compound 1 with acetyl chloride at room temperature [11].

Symmetrical Bis-arylidene Derivatives

Condensation of compound 1 with two equivalents of thiophene-3-carboxaldehyde and indole-3- carboxaldehyde afforded the corresponding bis-arylidenes 5 and 6 respectively. Compound 5 showed an NH absorption at 3266 cm-1, a band at 1683 cm-1 for the carbonyl group and 1625 cm-1 for C=C (See Table 2).
Molecules 05 00629 i002

Mono Arylidene and Unsymmetrical Bis-arylidene Derivatives

Condensation of piperazine-2,5-dione 1 with aromatic aldehydes always afforded symmetrical bis- arylidene derivatives. However, condensation using 1,4-diacetylpiperazine-2,5-dione 2 with aldehydes could be controlled to occur in a stepwise fashion. Two novel monoarylidenes 7 and 8 were synthe- sized from the reaction of equal molar quantities of 2 and the appropriate aldehyde.
The 1H-NMR spectrum of compound 7 showed a singlet at δ 4.5 ppm attributed to the methylene signal, indicative of a monoarylidene derivative. Its IR spectrum showed an NH absorption band at 3255 cm-1 and broad bands at 1693 cm-1 and 1661 cm-1 for the two C=O groups. The unsymmetrical diarylidene derivatives were prepared from the monoarylidene derivatives 7 and 8, as shown in Scheme 1.
Compound 10 was synthesized by condensing one equivalent of compound 7 with an equivalent amount of terephthalic aldehyde in dimethylformamide (DMF) at room temperature. The IR spectrum of compound 10 showed an absorption band at 1705 cm-1 for the aldehydic C=O group. Compound 10 readily undergoes a Knoevenagel condensation with malononitrile, using piperidine as a base, to afford the red dicyanomethylene adduct 11 in good yield. The IR spectrum of the latter showed a CN absorp-tion band at 2197 cm-1. The introduction of the powerful electron withdrawing group CH=C(CN) into the para position of the phenyl group in compound 11 gave a remarkable deepening in colour when compared with the yellow compound 10.
To get a clear insight into this colour change we synthesized the bisarylidene derivative 13 which contains a donor group on one arylidene ring and an acceptor on the other one. Compound 13 was pre- pared from the monoarylidene 7 and phthalic anhydride in good yield. The formation of the 1,3-dione derivative 13 is believed to occur via the intermediate 12. The structure of compound 13 was deduced from its IR spectrum which showed an absorption of the carbonyl groups of the 1,3-diketone moiety at 1670 cm-1, at a higher wavenumber than the 1750 cm-1 expected for compound 12. In the case of com- pound 13, despite the fact that it possesses the thienylidene donor moiety, the compound is yellow and no red shift was observed.
It was of interest to examine the effect of changing the electron donating arylidene moiety from 3- thienylidene to 4-dimethylaminobenzylidene on the colour of compound 11. Thus, we prepared com- pounds 14 and 15 by condensing compound 8 with 4-nitrobenzaldehyde and terephthalic aldehyde re- spectively (Scheme 2). In the event, despite having arylidene substituents with a donor and acceptor group present, no absorption shift to the red region was observed, the compound 14 was yellow in col- our. This suggests that in this system, the amide bond is not an efficient transmitter of the electronic effects and merostabilisation is not observed.
Compound 15 undergoes a Knovenagel condensation with malononitrile, in the same manner used to prepare its analogue 11, to give compound 16 as dark red crystals. Changing the donor moiety from a thienyl ring to 4-dimethylaminobenzylidene resulted in a noticeable red shift as the compound 16 is dark red in colour. The deepening of the colour observed in the case of compounds 11 and 16 is be- lieved to be due to the stabilization of half of the molecule brought about by the hybrid resonance structures 17 and 18 (Scheme 3).

Experimental

General

Melting points were recorded on a Thomas-Hoover capillary melting apparatus and are uncorrected. IR spectra were taken as KBr disks on a Nicolet Magna 520 FT IR spectrometer, 1H-NMR were re-corded as CDCl3 solutions on a Bruker DPX 400 MHz spectrometer using TMS as the internal stan-dard. Microanalyses were carried out using a Perkin Elmer 240B Analyzer. The following compounds were prepared by the previously reported literature methods: Piperazine-2,5-dione 1, m.p. > 300 °C [lit.[4], m.p. > 300 °C]; 1,4-diacetylpiperazine-2,5-dione 2, m.p. 98-100 °C [lit.[11], m.p. 99-100.5 °C]

3,6-Di(3-thienylidene)piperazine-2,5-dione 5 and 3,6-Di(3-indolylidene)piperazine-2,5-dione 6

A mixture of piperazine-2,5-dione 1 (0.01 mol), the appropriate aldehyde (0.02 mol) and anhydrous sodium acetate (0.04 mol) in acetic anhydride (15 ml) was refluxed for 5 hrs. The mixture was cooled, filtered and the solid washed with small amount of ether (see Table 1 & Table 2).

1-Acetyl-3-(3-thienylidene)piperazine-2,5-dione 7 and 1-Acetyl-3-(4-dimethylaminobenzylidene)pipe- razine-2,5-dione 8

A mixture of 1,4-diacetylpiperazine-2,5-dione 2 (0.01 mole), the appropriate aldehyde (0.01 mole) and triethylamine (0.01 mole) was stirred at room temperature for 12 hrs. The resulting precipitate was filtered off and washed with water. Recrystallization from ethanol gave the pure monosubstituted de- rivatives 7 and 8 (see Table 1 & Table 2).

General procedure for the preparation of unsymmetrical bisarylidenes:3-(3-Thienylmethylidene)-6-(4- dimethylaminobenzylidene)piperazine-2,5-dione 9, 3-(3-Thienylmethylidene)-6-(4-formylbenzylidene)- piperazine-2,5-dione 10, and 3-(3-Thienylmethylidene)-6-(1,3-dioxo-2-indanylidene)piperazine-2,5- dione 13

A solution of 1-acetyl-3-(3-thienylmethylidene)piperazine-2,5-dione 7 (0.01 moles), an aldehyde (0.01 moles) and triethylamine (0.01 moles) in DMF (25 ml) was stirred at 25 °C for 12 hrs. The pre- cipitate was filtered off and washed with water and a small amount of cooled ethanol (10 ml). The pure samples were obtained after recrystallization from dimethylformamide (see Table 1 & Table 2).

3-(4-Dimethylaminobenzylidene)-6-(4-nitrobenzylidene)piperazine-2,5-dione 14

This material was prepared from 1-acetyl-3-(4-dimethylaminobenzylidene) piperazine-2,5-dione 8 (1.0 mmole) and 4-nitrobenzaldehyde (1.0 mmole) using the same general procedure mentioned above (Table 1 & Table 2).

3-(3-Thienylmethylidene)-6-[4-(1,1-dicyanovinylbenzylidene)]piperazine-2,5-dione 11

Piperidine (0.5 ml) was added dropwise to a warm solution of the aldehyde 10 (0.5 g, 1.5 mmole) and malononitrile (0.1 g, 1.5 mmole) in ethanol (20 ml). A deepening in the colour of the solution was observed. The reaction mixture was refluxed for 3 hrs, then cooled. A dark red solid precipitated, which was filtered off and washed with cold ethanol and dried (see Table 1 & Table 2).

3-(4-Dimethylaminobenzylidene)-6-(4-formylbenzylidene)piperazine-2,5-dione 15

This compound was prepared from of 1-acetyl-3-(4-dimethylaminobenzylidene) piperazine-2,5- dione 8 (0.50g, 1.73 mmole), terephthalic aldehyde ( 0.23g, 1.73 mmole) and triethylamine (1.0 ml) in DMF (25 ml) using the same procedure employed to prepare compound 10 (Table 1 & Table 2).

3-[4-(1,1-Dicyanocinyl)benzylidene]-6-(4-dimethylaminobenzylidene)piperazine-2,5-dione 16

This compound was prepared from the aldehyde 15 (0.25 g, 0.7 mmole), malononitrile (0.05 g, 0.7 mmole) and piperidine (0.5 ml) in DMF (10 ml) using the same procedure described for preparation of compound 11 (see Table 1 & Table 2).

References and Notes

  1. Sammes, P.G. Fortschr. Chem. Org. Naturst. 1975, 33, 51.
  2. Anteunis, M. J. O. Bull. Soc. Chim. Belg. 1978, 87, 625.
  3. Shin, C. Heterocycles 1983, 20, 1407.
  4. Schott, H. F.; Larkin, J. B; Rockland, L. B.; Dunn, M. S. J. Org. Chem. 1947, 12, 490. [PubMed]
  5. Blake, K.W.; Porter, A. E. A.; Sammes, P. G. J. Chem. Soc. Perkin Trans. 1 1972, 2494.
  6. Baxter, R. A.; Spring, F. S. J. Chem. Soc. 1947, 1179.
  7. Machin, P. J.; Porter, A. E.; Sammes, P. G. J. Chem. Soc. Perkin Trans. 1 1973, 404.
  8. Shin, C.; Nakajima, Y.; Sato, Y. Chem. Lett. 1984, 1301.
  9. Sakata, K.; Massgo, H.; Sakurai, A.; Takahashi, N. Tetrahedron Lett. 1982, 23, 2095.
  10. Shin, C.; Masaki, M.; Ohta, M. J. Org. Chem. 1967, 32, 1860.
  11. Marcuccio, S. M.; Elix, J. A. Aust. J. Chem. 1984, 37, 1791.
  • Samples Availability: Available from the authors.
Scheme 1.
Scheme 1.
Molecules 05 00629 sch001
Scheme 2.
Scheme 2.
Molecules 05 00629 sch002
Scheme 3.
Scheme 3.
Molecules 05 00629 sch003
Table 1. Physical and analytical data of synthesized compounds.
Table 1. Physical and analytical data of synthesized compounds.
Comp
No.
Yield
(%)
M.p.
(°C)
Colour of crystalsMolecular formulaCalculated (%)Found (%)
CHNCHN
573> 340YellowC14H10N2O2S255.633.319.2755.353.529.52
685> 340YellowC22H14N4O272.133.8315.371.883.9415.5
786> 320YellowC11H10N2O3S52.804.0011.252.653.8511.1
880> 320YellowC15H17N3O362.725.9214.662.546.1114.8
992> 320YellowC18H17N3O2S63.715.0112.463.665.3312.11
1089> 300YellowC17H12N2O3S62.963.708.6462.753.868.75
1187> 340Dark RedC20H12N4O2S64.523.2215.0564.323.4215.38
1392> 340YellowC17H10N2O4S60.362.968.2860.223.128.42
1494> 340YellowC20H18N4O463.494.7614.8263.224.8514.95
1575> 320OrangeC21H19N3O369.825.2611.6369.595.4111.75
1652>340Dark RedC24H19N5O270.424.6417.1270.214.7117.41
Table 2. IR and 1H -NMR data of synthesized compounds.
Table 2. IR and 1H -NMR data of synthesized compounds.
Comp No.δνmax/cm-1
NHAr-H +-CH=C-OtherNHC=OC=COther
510.346.70-7.90 326616831625
610.847.10-8.40 32201702,
1665
1640
711.116.82-7.614.50 (s, 2H, CH2),
2.43 (s, 3H, CH3CO)
32551693,
1661
1625
810.347.00-7.554.42 (s, 2H, CH2),
3.01 (s, 6H, (CH3)2N),
2.49 (s, 3H, CH3CO)
33201693,
1651
1609
910.726.88-7.603.07 (s, 6H, (CH3)2N)3200168316111705 (C=O)
1011.856.95-7.609.80 (s, 1H, CHO)31651694,
1682
16121705 (C=O)
1110.726.81-7.908.3 (s, 1H, CH=C(CN)2)3193168816052197 (CN)
1310.856.66-8.20 3205167016031695 (C=O)
1410.896.82-8.603.1 (s, 6H, (CH3)2N)32251698,
1645
158.116.70-8.369.5 (s, 1H, CHO)31951687,
1652
16111698 (C=O)
168.246.65-8.08.14 (s, 1H, CH=C(CN)232111682,
1650
16252197 (CN)

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MDPI and ACS Style

Asiri, A.M. New Conjugated Systems Derived from Piperazine-2,5-dione. Molecules 2000, 5, 629-636. https://doi.org/10.3390/50300629

AMA Style

Asiri AM. New Conjugated Systems Derived from Piperazine-2,5-dione. Molecules. 2000; 5(3):629-636. https://doi.org/10.3390/50300629

Chicago/Turabian Style

Asiri, Abdullah Mohamed. 2000. "New Conjugated Systems Derived from Piperazine-2,5-dione" Molecules 5, no. 3: 629-636. https://doi.org/10.3390/50300629

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